布洛芬混悬滴剂和对乙酰氨基酚治疗小儿热性惊厥的疗效观察

目的观察布洛芬混悬滴剂和对乙酰氨基酚治疗小儿热性惊厥(FS)的疗效。方法选取2017年4月-2019年4月于本院就诊的FS患儿80例,随机分为对照组与观察组,每组40例,均进行抗惊厥、物理降温等常规治疗,在此基础上,对照组采用对乙酰氨基酚治疗,观察组采用布洛芬混悬滴剂治疗,观察2组临床疗效、退热效果、实验室检查结果(血红蛋白、血钠、血钙)及不良反应情况。结果对照组治疗总有效率为77.5%,观察组为95%,差异有统计学意义(P<0.05);治疗后1 h,2组患儿体温差异无统计学意义(P>0.05),治疗后3 h、6 h,2组体温均低于服药前,观察组患儿体温低于对照组,差异有统计学意义(P<0.05);治疗后,2组血红蛋白、血钠、血钙浓度较服药前均显著升高(P<0.05),且观察组高于对照组(P<0.05);对照组不良反应率为7.5%,观察组为5%,差异无统计学意义(P>0.05)。结论布洛芬混悬滴剂对小儿热性惊厥临床症状改善作用显著,值得推介。

Efficacy of respective ibuprofen suspension drops and acetaminophen in treatment of febrile seizures of children

Objective To evaluate the efficacy of respective ibuprofen suspension drops and acetaminophen in the treatment of febrile seizures (FS) of children. Methods Eighty children patients with FS treated in a hospital from April 2017 to April 2019 were selected and randomly divided into a control group and a trial group, with 40 cases in each group. The two groups were treated with anticonvulsant and physical cooling. On this basis, the control group was treated with acetaminophen, and the trial group was treated with ibuprofen suspension drops. The clinical efficacy, antipyretic effects, laboratory tests (hemoglobin, blood sodium, blood calcium) and adverse reactions were observed and compared between the two groups. Results The total effective rate was 80% in the control group and 95% in the trial group (P<0.05). One hour after the treatment, there was no significant difference in body temperature between the two groups (P>0.05). Three hours and 6 hours after the treatment, the body temperature was lower than that before the treatment in both groups, however, the temperature in the trial group was lower than that in the control group (P<0.05). After the treatment, the levels of hemoglobin, blood sodium and blood calcium in the two groups were significantly increased compared with those before the treatment (P<0.05), and these indicators in the trial group were higher than those in the control group (P<0.05). The adverse reaction rate was 7.5% in the control group and was 5% in the trial group (P>0.05). Conclusion Ibuprofen suspension drops has a significant effect on the improvement of clinical symptoms of febrile seizures of children. It is worthy of recommendation.