| PSA?F/T值与PSAD在前列腺穿刺活检中诊断价值的探讨 |
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| 引用本文： | 潘〓彬,陆〓叶,陆〓明,朱〓江.PSA?F/T值与PSAD在前列腺穿刺活检中诊断价值的探讨[J].南京医科大学学报,2010(4):514-517. |
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| 作者姓名： | 潘〓彬 陆〓叶 陆〓明 朱〓江 |
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| 作者单位： | 南通市第一人民医院泌尿外科;上海交通大学附属第一人民医院泌尿外科; |
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| 基金项目： | 上海市宝山区科委基金资助(05-E-2) |
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| 摘 要： | 目的:探讨前列腺特异抗原(PSA)、游离PSA/总PSA(F/T)比值及前列腺特异抗原密度(PSAD)在前列腺穿刺活检中的诊断价值。方法:选取2006年1月～2008年12月经直肠超声引导下前列腺穿刺活检患者285例,检测血清总PSA、游离PSA,计算F/T及PSAD,探讨穿刺诊断前列腺癌(PCa)最佳的PSA、F/T值与PSAD值。结果:以PSA>15ng/ml为临界值,PSA诊断前列腺癌的灵敏度为70.0%,特异度为68.5%,阳性预测值为58.6%;在PSA<15ng/ml区域,良性前列腺增生(BPH)组与PCa组间PSA差别无显著性(t=0.018,P>0.05),此时两组间F/T值及PSAD比较,差别均有显著统计学意义(t=4.137、3.158,P<0.01)。F/T值取0.16,PSAD取0.35ng/(ml·cm3)时,F/T值及PSAD诊断PCa的灵敏度、特异度、阳性预测值均较高。结论:PSA>15ng/ml时高度怀疑前列腺癌;在PSA<15ng/ml时联合应用F/T值和(或)PSAD可以明显提高前列腺癌的穿刺检出率。
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| 关 键 词： | 前列腺癌 前列腺特异性抗原 前列腺特异性抗原密度 |
| 收稿时间： | 2009/11/20 0:00:00 |
Rediscussion of diagnositic value of PSA,F/T ratio and PSAD in prostate biopsy |
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| PAN Bin,LU Ye,LU Ming and ZHU Jiang.Rediscussion of diagnositic value of PSA,F/T ratio and PSAD in prostate biopsy[J].Acta Universitatis Medicinalis Nanjing,2010(4):514-517. |
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| Authors: | PAN Bin LU Ye LU Ming and ZHU Jiang |
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| Institution: | Department of Urology/a>;Nantong Frist People's Hospital/a>;Nantong 226001/a>;1Department of Urology/a>;Shanghai First People's Hospital Affiliated to Shanghai Jiaotong University/a>;Shanghai 200080/a>;China |
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| Abstract: | Objective:To evaluate diagnositic value of prostate specific antigen (PSA),free/total PSA (F/T PSA),and PSA density (PSAD) in prostate biopsy. Methods:Total serum PSA and free PSA were detected while F/T PSA value and PSAD were calculated in 285 patients who underwent transrectal ultrasonography-guided prosate biopsy. Optimum PSA,F/T PSA value and PSAD for detecting Pca were discussed. Results:When the cut off value of PSA was set as>15 ng/ml,the diagnostic sensitivity,specificity and the positive predictiv... |
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| Keywords: | prostate cancer prostate specific antigen prostate specific antigen density |
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