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| 子宫内膜癌DNA倍体及S期细胞比率测定的临床意义 | |
| 引用本文： | 张秋实,史肇光,李继俊. 子宫内膜癌DNA倍体及S期细胞比率测定的临床意义[J]. 现代妇产科进展, 2001, 10(5): 359-361 |
| 作者姓名： | 张秋实 史肇光 李继俊 |
| 作者单位： | 1. 山东省立医院妇产科 2. 内蒙古医学院附属医院妇产科 |
| 摘 要： | 目的 :研究DNA倍体、S期细胞比率 (SPF)在子宫内膜复合型增生、子宫内膜癌不同临床分期和病理分级中的变化并评价其临床意义。方法 :采用流式细胞术(FCM)测定 39例子宫内膜癌 ,8例复合型增生子宫内膜中DNA倍体和SPF的变化。结果 :DNA异倍体率和SPF在子宫内膜癌中高于复杂型增生子宫内膜 (P <0 0 1) ,晚期、低分化和深肌层浸润子宫内膜癌DNA异倍体率和SPF高于早期、高分化、浅肌层浸润子宫内膜癌。结论 :DNA异倍体率、S期细胞比率在子宫内膜癌的诊断和鉴别诊断、监测病情变化和评价预后方面有重要的临床意义。 |
| 关 键 词： | 子宫内膜肿瘤 DNA倍体 S期细胞比率 |
| 文章编号： | 1004-7379(2001)05-0359-03 |
| 修稿时间： | 2001-05-17 |
Detectation of DNA ploidy and S-phase fraction in human endometrial carc inoma |
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| Zhang Qiushi,Shi Zhaoguang,Li Jijun.. Detectation of DNA ploidy and S-phase fraction in human endometrial carc inoma[J]. Current Advances In Obstetrics and Gynecology, 2001, 10(5): 359-361 | |
| Authors: | Zhang Qiushi Shi Zhaoguang Li Jijun. |
| Affiliation: | Zhang Qiushi1,Shi Zhaoguang2,Li Jijun1.1.Department of Obstetrics and Gynecology,Shandong Province Hospital,Jinan 250025,2.Department of Obstetrics and Gynecology,the Affiliated Hospital of Inner Mongolia Medical College |
| Abstract: | Objective:To study the significance of DNA ploidy and S-phase fraction(SPF) in complex hyperplasia of the endometrium and different clinical stages and grades of endometrial carcinomas.Methods:DNA ploidy and SPF were detected in 39 cases of endometrial carcinoma,8 cases of complicated hyperplasia endometrium by flow cytometry.Results:Aneuploidy rate and SPF of the endometrial carcinoma were higher than that of complex hyperplasia of the endometrium.The aneuploidy rate and SPF in advanced stage,grade Ⅲ and deep myometrial invasion were significantly higher than that of the grade Ⅰ,non-myometrial invasion and stage Ⅰ of endometrial carcinoma.Conclusions:The aneuploidy rate and SPF may play as the parameters of the diagnosis,assessment of the progression and prognosis of endometrial carcinoma. |
| Keywords: | Endometrial neoplasms DNA ploidy S-phase fraction |
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