| 乳核分散片的制备工艺 |
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| 引用本文： | 万艳群,任卫琼,欧阳荣,谢瑜,罗懿,邓桂明. 乳核分散片的制备工艺[J]. 中国药师, 2013, 16(7): 972-974 |
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| 作者姓名： | 万艳群 任卫琼 欧阳荣 谢瑜 罗懿 邓桂明 |
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| 作者单位： | 1. 湖南中医药大学药学院,长沙,410073
2. 湖南中医药大学第一附属医院 |
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| 基金项目： | 湖南省卫生厅基金项目（编号：201166） |
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| 摘 要： | 目的:优选乳核分散片的处方和制备工艺参数.方法:以崩解时限和片剂外观作为考察指标,采用均匀设计法优选乳核分散片的处方和制备工艺参数.结果:最佳乳核分散片处方为:38%浸膏粉、46%微晶纤维素(MCC)、8%低取代羟丙基纤维素(L-HPC)、4%羧甲基淀粉钠(CMS-Na)、2%交联聚乙烯吡咯烷酮(PVPP)、2%微粉硅胶;优选的分散片处方崩解时间小于3 mim,分散均匀.结论:优选处方合理,工艺可行,所制备的乳核分散片质量符合相关要求.
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| 关 键 词： | 分散片 均匀设计 制备工艺 |
| 收稿时间： | 2013-02-17 |
| 修稿时间： | 2013-04-09 |
Preparation of Ruhe Dispersible Tablets |
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| Wan Yanqun,Ren Weiqiong,Ouyang Rou,Xie Yu,Luo Yi and Deng Guiming. Preparation of Ruhe Dispersible Tablets[J]. China Pharmacist, 2013, 16(7): 972-974 |
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| Authors: | Wan Yanqun Ren Weiqiong Ouyang Rou Xie Yu Luo Yi Deng Guiming |
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| Affiliation: | Hunan University of Traditional Chinese Medicine, Changsha 410073, China;The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine;The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine;Hunan University of Traditional Chinese Medicine, Changsha 410073, China;Hunan University of Traditional Chinese Medicine, Changsha 410073, China;The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine |
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| Abstract: | ABSTRACT Objective: To optimize the formula and preparation technology of Ruhe dispersible tablets.Method:The disintegration time and the appearance were observed to screen the optimal preparation technology of Ruhe dispersible tablets by uniform experiment. Result: The optimized formula of Ruhe dispersible tablets was as follows: 38% extract powder, 47% MCC, 8% L-HPC, 4% CMS-Na, 2% PVPP and 2% aerosil. The optimized dispersible tablets could disintegrate uniformly in 3 minutes, showing promising distribution homogeneity. Conclusion:The optimized formula is reasonable, and the preparation technology is feasible. The quality of Ruhe dispersible tablets is accorded with the related standards. |
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| Keywords: | Dispersible tablets Uniform experiment Preparation process |
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