| 微核试验评价含磷酸氢钙涂层纯镁材料的致突变性 |
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| 引用本文： | 李德超,吴艳娟,胡津,刘广义,赵刚. 微核试验评价含磷酸氢钙涂层纯镁材料的致突变性[J]. 口腔材料器械杂志, 2011, 20(2): 85-87 |
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| 作者姓名： | 李德超 吴艳娟 胡津 刘广义 赵刚 |
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| 作者单位： | 1. 佳木斯大学口腔医学院,佳木斯,154002
2. 哈尔滨工业大学材料科学与工程学院,哈尔滨,150001 |
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| 基金项目： | 黑龙江省卫生厅科技项目(2009-36) 佳木斯大学科学技术研究项目 |
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| 摘 要： | 目的通过微核实验检测纯镁微弧氧化（MAO）、二水磷酸氢钙（DCPD）涂层对小鼠的致突变性以评价其生物相容性。方法 30只小鼠,随机分为5组,阴性对照和实验组按50m l/kg分别腹腔注射生理盐水、三种材料浸提液,阳性对照组腹腔注射环磷酰胺（CP）（40mg/kg）,二次注射后6h处死小鼠,取其股骨制备骨髓涂片,观察P/N值,计算微核率。结果各实验组微核率均小于5‰,实验组与阴性对照组无显著差异,与阳性对照组有显著差异。结论涂层后的纯镁对小鼠无潜在的致突变性。
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| 关 键 词： | 纯镁 微弧氧化 二水磷酸氢钙 微核 |
Evaluation on the mutagenicity of bioactive calcium phosphate coating formed magnesium materials by micronucleus test |
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| Li Dechao,Wu Yanjuan,Hu Jin,Liu Guangyi,Zhao Gang. Evaluation on the mutagenicity of bioactive calcium phosphate coating formed magnesium materials by micronucleus test[J]. Chinese Journal of Dental Materials and Devices, 2011, 20(2): 85-87 |
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| Authors: | Li Dechao Wu Yanjuan Hu Jin Liu Guangyi Zhao Gang |
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| Affiliation: | Li Dechao1,Wu Yanjuan1,Hu Jin2,Liu Guangyi2,Zhao Gang1(1.School of Stomatology,Jiamusi University,Jiamusi 154002,2.School of Materials Science and Engineering,Harbin Institute of Technology,Harbin 150001) |
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| Abstract: | Objective To study the mutagenicity of micro-arc oxidized magnesium(MAO) and bioactive calcium phosphate coating formed by micro-arc oxidized magnesium(DCPD),detect its teratogenic effect on the mice with a micronucleus test.Methods 30 healthy mice were randomly divided into 5 groups.The pure magnesium(MG),MAO,DCPD extracts and physiological saline were given via abdominal cavity injection,serving as a negative control with the concentration of 50mg/kg,while cyclophosphamide(40mg/kg) as a positive control,t... |
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| Keywords: | Pure magnesium Micro-arc oxidized Bioactive calcium phosphate coating formed Micronucleus |
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