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Relapsed childhood acute myeloid leukemia patient with inversion of chromosome 16 harboring a low FLT3 internal tandem duplication allelic burden and KIT mutations |
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| Authors: | Ai Yamada Hiroshi Moritake Mariko Kinoshita Daisuke Sawa Sachiyo Kamimura Shotaro Iwamoto Yuka Yamashita Jiro Inagaki Takahide Takahashi Akira Shimada Megumi Obara Hiroyuki Nunoi |
| Affiliation: | 1. Division of Pediatrics, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan;2. Department of Pediatrics, Mie University Graduate School of Medicine, Mie, Japan;3. Clinical Research Center, National Hospital Organization Nagoya Medical Center, Aichi, Japan;4. Department of Pediatrics, National Kyushu Cancer Center, Fukuoka, Japan;5. Department of Medical Support, Okayama University Hospital, Okayama, Japan;6. Department of Pediatrics, Okayama University Graduate School of Medicine, Okayama, Japan |
| Abstract: | Inversion of chromosome 16 [inv(16)] has a good prognosis in acute myeloid leukemia (AML), but additional genetic aberrations influence the outcome. We herein describe the case of a 15‐year‐old Japanese boy with inv(16) harboring a low‐allelic burden internal tandem duplication of FLT3 (FLT3‐ITD) and KIT mutations. Conventional chemotherapy eradicated a clone with a low‐allelic burden FLT3‐ITD mutation, although another clone with a KIT mutation occurred 17 months later. Further investigation is necessary to identify AML with inv(16) conferring poor prognosis, to facilitate appropriate treatment with additional drugs, such as dasatinib or gemtuzumab ozogamicin. |
| Keywords: | acute myeloid leukemia allelic burden FLT3‐internal tandem duplication inv(16) KIT |