| 抗结核药物作用机制及构效关系的研究进展 |
| |
| 引用本文： | 蔡志强,祝 石,孙铁民. 抗结核药物作用机制及构效关系的研究进展[J]. 中国药物化学杂志, 2009, 19(5): 382-389 |
| |
| 作者姓名： | 蔡志强 祝 石 孙铁民 |
| |
| 作者单位： | 沈阳药科大学 制药工程学院，辽宁 沈阳110016 |
| |
| 摘 要： | 在过去的几十年里，随着艾滋病(AIDS)的蔓延，结核病的发病率也在逐渐增多，除结核病外，由分支杆菌所引起的其他疾病也开始传播，HIV感染患者特别容易受分支杆菌的感染，该文主要针对抗结核药物的作用机制以及构效关系(SARs)进行简要的综述，以便能更好的、合理的使用抗结核药物。
|
| 关 键 词： | 结核分支杆菌；肺结核；多重耐药性；活性机制；构效关系 |
| 收稿时间： | 2009-03-20 |
| 修稿时间： | 2009-07-15 |
Research advances on the activity mechanism and structure-activity relationships of anti-tuberculosis agents |
| |
| CAI Zhi-qiang,ZHU Shi,SUN Tie-min. Research advances on the activity mechanism and structure-activity relationships of anti-tuberculosis agents[J]. Chinese Journal of Medicinal Chemistry, 2009, 19(5): 382-389 |
| |
| Authors: | CAI Zhi-qiang ZHU Shi SUN Tie-min |
| |
| Affiliation: | School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China |
| |
| Abstract: | In the past few decades, with the prevalence of AIDS, tuberculosis has begun to comeback and spread. In addition to tuberculosis, diseases caused from Mycobacterium also began to become more prevalent, HIV-infected patients were particularly vulnerable to mycobacterial infections, incidence rate of such diseases and the resulting burden is very argent in the global. The mechanism and structure-activity relationships (SARs) of anti-tuberculosis agents were briefiy reviewed. |
| |
| Keywords: | Mycobacterium tuberculosis tuberculosis multi-drug resistance activity mechanism structure-activity relationships (SARs |
|
| 点击此处可从《中国药物化学杂志》浏览原始摘要信息 |
|
点击此处可从《中国药物化学杂志》下载全文 |
