The quinazoline-2,4(1H,3H)-diones skeleton: A key intermediate in drug synthesis |
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Authors: | Davood Gheidari Morteza Mehrdad Saloomeh Maleki |
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Affiliation: | 1. Department of Chemistry, Faculty of Science, University of Guilan, Rasht, Iran;2. Department of Chemistry, Faculty of Science, University of Shahrood, Iran |
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Abstract: | Quinazoline-2,4(1H,3H)-dione is a major class of N-fused heterocyclic with a wide range of biological functions, including anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities, and other activities, has attracted high attention in organic and medicinal chemistry. As a consequence, all chemists and pharmaceutical chemists should be familiar with the various procedures for producing quinazoline-2,4(1H,3H)-dione. The main purpose of this paper is to provide an overview of the many manufacturing methods for various biological compounds based on the quinazoline-2,4(1H,3H)-dione and 2,4-dichloroquinazoline cores. |
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Keywords: | Dichloroquinazoline |
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