川乌通络方治疗糖尿病周围神经病变80例疗效观察

目的观察川乌通络方治疗糖尿病周围神经病变(DPN)疗效和安全性。方法将160例DPN符合气虚(阳虚)血瘀证的患者随机分为治疗组和对照组各80例。2组均接受糖尿病常规治疗,并禁用任何改善血液循环和影响神经传导的药物。治疗组给予川乌通络方水煎服,每日1剂。对照组给予α-硫辛酸600 mg,每日1次。疗程均为3周。观察治疗前后患者肢体肌电图,记录治疗前后腓总神经及尺神经的神经传导速度(MCV、SCV)。观察2组疗效与不良反应。结果治疗组总有效率(87.5%)显著高于对照组(75.0%),差异有统计学意义(P<0.05);2组神经传导速度明显提高(P<0.05,P<0.01),且治疗组优于对照组(P<0.05,P<0.01),2组均未见明显不良反应。结论川乌通络方可明显提高糖尿病周围神经病变的疗效,且无明显不良反应。

Therapeutic efficacy observation on Chuanwutongluo recipe in treating diabetic peripheral neuropathy:80 cases report

Objective To observe the efficacy and safety of Chuanwutongluo recipe in treating diabetic peripheral neuropathy（DPN）.Methods 160 cases of diabetic peripheral neuropathy with deficiency of Qi（Yang）and blood stasis syndrome were randomly divided into treatment group and control group with 80 cases in each group.Two groups were treated with conventional diabetes therapy,and disable drugs with any improvement in blood circulation and influence in nerve conduction. The treatment group was given a dose of daily Chuanwutongluo recipe decocted in water.The control group was givenα-lipoic acid 600 mg QD.Both groups were treated for 3 weeks.The clinical manifestations of scoring method were used as the observation records of patients＇ clinical efficacy of objective index.Patients of both groups were observed common peroneal nerve and ulnar nerve conduction velocity（MCV,SCV）recorded by limb electromyography before and after the treatment,and recorded the efficacy and adverse reaction.Results The total effective rate of treatment group（87.5%）was significantly higher than that in control group（75.0%,P 0.05）;the nerve conduction velocity of treatment group was significantly increased （P 0.05,P 0.01）.The two groups were no obvious adverse reaction.Conclusion Chuanwutongluo recipe can significantly improve the therapeutic effect on peripheral neuropathy of diabetes.