| 奥洛他定温度敏感眼用原位凝胶的制备 |
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| 引用本文： | 马凤余,胡容峰,徐亚静,胡晓. 奥洛他定温度敏感眼用原位凝胶的制备[J]. 中国医院药学杂志, 2012, 0(11): 858-861 |
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| 作者姓名： | 马凤余 胡容峰 徐亚静 胡晓 |
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| 作者单位： | 安徽新华学院药学院;安徽中医学院药学院 |
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| 摘 要： | 目的:研制奥洛他定温度敏感眼用原位凝胶。方法:采用泊洛沙姆P407和P188为温敏材料,以胶凝温度为指标,通过星点设计-效应面法优化处方。结果:经过优化筛选出的处方在室温条件下是自由流动的液体,在生理条件下发生胶凝形成凝胶。结论:所研制奥洛他定眼用温度敏感原位凝胶符合眼部应用要求,体现出良好的临床应用前景。
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| 关 键 词： | 奥洛他定 温度敏感 原位凝胶 制备 |
Preparation of olopatadine in situ thermosensitive gel for ophthalmic use |
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| MA Feng-yu,HU Rong-feng,XU Ya-jing,HU Xiao. Preparation of olopatadine in situ thermosensitive gel for ophthalmic use[J]. Chinese Journal of Hospital Pharmacy, 2012, 0(11): 858-861 |
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| Authors: | MA Feng-yu HU Rong-feng XU Ya-jing HU Xiao |
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| Affiliation: | 1.School of Pharmacy,Anhui Xinhua University,Anhui Hefei 230088,China;2.School of Pharmacy,Anhui College of Traditional Chinese Medicine,Anhui Hefei 230038,China) |
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| Abstract: | OBJECTIVE To prepare olopatadine in situ thermosensitive gel for ophthalmic use.METHODS The olopatadine thermosensitive gel was prepared with poloxamer 407 and poloxamer 188 as thermosensitive material,the formulation was optimized by central composite design-response surface method.RESULTS An optimized formulation was a freely flowing liquid at room temperature and converted to a firm gel in the physiological condition.CONCLUSION Olopatadine in situ thermosensitive gel accorded with the requirement for ophthalmic application and showed great potential in ophthalmic application. |
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| Keywords: | olopatadine thermosensitive in situ gel preparation |
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