基于BDNF假说的度洛西汀治疗抑郁症的相关研究

抑郁症是一种常见的情感性精神障碍,目前发病机制尚不明确。抑郁症有多种生物学假说,其中神经营养假说认为,神经营养因子对神经生长、存活和可塑性具有重要的作用。在哺乳动物中,脑源性神经营养因子（BDNF）是一种重要的神经营养因子,BDNF 水平的降低可能是抑郁症发病的重要机制之一。度洛西汀是临床上常用的SNRI 类抗抑郁剂,动物实验和临床研究均表明度洛西汀发挥抗抑郁作用可能与BDNF 通路有着紧密的联系。BDNF 的表达可能与抗抑郁疗效、认知功能的改善相关。本文对基于BDNF 假说的度洛西汀治疗抑郁症的研究进行综述。

Literature review of duloxetine in the treatment of depression based on the BDNF hypothesis

Depression is a common affective disorder,and its pathogenesis is currently unknown.There are a variety of biological hypotheses for depression,in which the neurotrophic hypothesis believes that neurotrophic factors play an important role in nerve growth,survival and plasticity.In mammals,brain-derived neurotrophic factor(BDNF) is an important neurotrophic factor,and the decrease of BDNF level may be one of the important mechanisms of depression.Duloxetine is a commonly used SNRI antidepressant in clinical practice.Both animal experiments and clinical studies have shown that duloxetine may play an antidepressant role and may be closely related to the BDNF pathway.The expression of BDNF may be associated with an improvement in antidepressant efficacy and cognitive function.This article reviews the studies of duloxetine in the treatment of depression based on the BDNF hypothesis.