注射用加替沙星与维生素B_6配伍稳定性考察

目的考察注射用加替沙星和维生素B6在5%葡萄糖注射液中的稳定性。方法采用高效液相色谱法测定注射用加替沙星与维生素B6配伍后在25℃下6 h内的含量变化,并观察和检测配伍液的外观及pH变化。结果配伍液外观性状无变化,pH基本不变,加替沙星与维生素B6的相对百分含量在95%以上。结论加替沙星和维生素B6在5%葡萄糖注射液中在6 h内配伍稳定。

Study on compatible stability of gatifloxacin for injection and vitamin B_6 injection

Objective To study the compatible stability of gatifloxacin for injection with vitamin B6 injection in 5% glucose injection.Methods The content of the mixture of gatifloxacin for injection with vitamin B6 injection in 5%glucose injection within 6 hours at 25 ℃ was determined by HPLC,and the appearance of the mixture was observed and its pH value was determined.Results The appearance of the mixture showed no change,and no significant change in pH value was observed,the relative content of gatifloxacin and vitamin B6 was higher than 95%.Conclusion The mixture of gatifloxacin for injection with vitamin B6 injection was stable in 5%glucose injection within 6 hours.