喉鳞状细胞癌Cath-D和CD44的免疫组织化学检测

为研究组织蛋白酶－D（Cath－D）和CD44表达与喉癌临床、病理和预后的关系，采用免疫组织化学方法检测Cath－D和CD44在96例喉鳞状细胞癌中的表达情况。结果显示，Cath－D和CD44在喉癌中表达的阳性率分别为52．1％和41．7％；Cath－D的阳性表达与喉癌转移（包括颈淋巴结转移和远处转移）呈正相关，但单独与颈淋巴结转移无关，CD44表达与转移无关；另外，Cath－D和CD44表达与喉癌分期、细胞的病理分级、肿瘤大小和术后3年生存率均无关。提示，Cath－D在喉癌发生转移过程中可能起到一定作用。

Immunohistochemical study of Cath-D and CD44 in laryngeal squamous cell carcinomas

The expression of Cath-D and CD44 was examined immunohistochemically in 96 laryngeal squamous cell carcinomas and compared with clinic pathological feature. Expression of Cath-D and CD44 was detected in 52.1% and 41. 7% respectively. The correlation was observed between Cath-D expression and metastasis (including lymph node metastasis and distant metastasis), but Cath-D expression was not associated with lymph node metastasis. Expression of CD44 was not associated with lymph node metastasis also. In addition, expression of Cath-D and CD44 did not correlated with clinical stage, histologic grade, size of tumor and postoperative 3 years survival rates. Our results indicate that Cath-D may play a role in metastasis.