党参炮制原理探讨

目的：探讨党参的炮制原理。方法：采用HPLC对党参及米炒党参化学成分进行比较分析,对炮制品中新增成分进行分离纯化和结构鉴定,并模拟炮制实验过程对炮制品中新增成分的生成途径进行探讨。结果：分离得到党参炮制品中特征性成分,经结构鉴定为5-羟甲基-2-糠醛,党参多糖与阿魏酸等有机酸高温加热是生成5-羟甲基-2-糠醛的主要途径。结论：首次发现、分离党参炮制品中特征性成分并对其生成途径进行深入探讨,为进一步阐明党参炮制原理提供依据。

Discussion of Processing Principle of Dangshen

Objective ：To research the processing principle of Dangshen [ Codonopsis pilosula （ Franch. ） Nannf]. Methods： We used HPLC method to compare differences of chemical composition between crude Dangshen and its processed product, isolated and purified newly formed composition, determined its structure, and simulated reaction process to discover how the composition is formed. Results： One distinctive composition - 5-hydroxymethyl-2-furaldehyde （5-HMF）-was identified after processing, which is the product of Polysaccharides and organic acid （including Ferulic acid） reacting under high temperature. Conclusion：The distinctive composition of 5-HMF was for the first time, identified and isolated from Dangshen＇ s processed product. With deep analysis of reaction process, this study provides evidences for further research on processing principle of Dangshen.