晚期前列腺癌的间歇雄激素阻断治疗

目的：了解间歇雄激素阻断（IAD）方法对晚期前列腺癌的治疗作用。方法：回顾性分析21例晚期前列腺癌病人，应用药物诺雷德去势加氟他胺（甲组）或康士得IAD方法（乙组）治疗的结果。结果：21例患者经IAD治疗后，绝大多数取得了较好的疗效。甲组3年生存率为72．7％，乙组为80．0％，总3年生存率为76．2％。治疗间歇中减少了抗激素药物的应用，从而明显减少了潮红、体重增加及忧郁等内分泌治疗的副作用。结论：IAD治疗能推迟雄激素依赖性前列腺癌细胞向非依赖性细胞的转化，同时减少药物用量和毒副作用，明显改善患者的生活质量并降低治疗费用。

Intermittent androgen deprivation therapy for advanced prostate cancer

Objective To evaluate the effect of the intermittent androgen deprivation(IAD) on the treatment of advanced prostate cancer.Method 21 patients treated with IAD by LHRH analogues(zoladex) and androgen blockade(flutamide or cascodex) were reviewed retrospectively.Results IAD improves the life quality of patients with advanced prostate cancer.The 3-years survival rates of the patients treated with IAD by flutamide and cascodex were(72.7%) and 80.0% respectively.The overall 3 years survival rates of IAD was 76.2%.During the intermittence,the dose of drug was decreased,and such side effects as hot flashes,depression and weight gain were relieved.Conclusion IAD in treating advanced prostate cancer prolongs the duration of androgen dependence and decreases the dose of drug,also it minimizes the side effects and cost of therapy.