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| 用重组人白细胞介素2诱导人肺癌浸润淋巴细胞的LAK样活性 | |
| 引用本文： | 张月桂,徐震逸,巴德年,邵杰,李永堂,陈云富. 用重组人白细胞介素2诱导人肺癌浸润淋巴细胞的LAK样活性[J]. 哈尔滨医科大学学报, 1988, 0(4) |
| 作者姓名： | 张月桂 徐震逸 巴德年 邵杰 李永堂 陈云富 |
| 作者单位： | 哈尔滨医科大学肿瘤研究所(张月桂，徐震逸，巴德年)，哈尔滨医科大学三院外科(邵杰，李永堂)，哈尔滨医科大学三院外科(陈云富) |
| 摘 要： | 淋巴细胞浸润肿瘤组织的现象已被广泛注意,但对TIL的抗肿瘤作用进行研究只是近二三年才开始。这主要是由于基因工程技术的进步,使人们可以获得大量纯一的重组白细胞介素2(rIL-2),从而可进行TIL的活化,增殖,扩增的研究。我们用人rIL-2对 |
Induction of LAK Activity from Lymphocytes Infiltrating Human Lung Carcinomous Tissue by Human Recombinant Interleukin-2 (rlL-2) |
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| Zhang Yuegui. Induction of LAK Activity from Lymphocytes Infiltrating Human Lung Carcinomous Tissue by Human Recombinant Interleukin-2 (rlL-2)[J]. Journal of Harbin Medical University, 1988, 0(4) | |
| Authors: | Zhang Yuegui |
| Affiliation: | Institute of Oncology |
| Abstract: | We Investigated antitumor activity of tumor infiltrating lymphocytes(TIL) obtained from human carcinomous tissue. The results showed: 1) a large number of TIL could be obtained from tumor tissue by methods of enzymic isolation and Ficoll gradient centrifugation. The ratio of TIL and tumor cells varied in the samples; 2) after incubation of TIL with rIL-2 lymphoblasts appeared in the culture. Aggregates consisting of fast-growing cells were observed; 3) TIL from 5 lung tumor samples demonstrated significant cytotoxic activity against NK-resistant Anip targets after co-culture with rIL-2. Further investigations on other antitumor properties of TIL are being continued. |
| Keywords: | LAK TIL rIL-2 lung tumor |
| 本文献已被 CNKI 等数据库收录！ | |