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Effects of guanethidine sympathectomy on feeding, drinking, weight gain and amphetamine anorexia in the rat
Authors:P H Freeman  P J Wellman  D E Clark
Affiliation:Department of Psychology, Texas A&M University USA;The United States Department of Agriculture, College Station, TX 77843 USA
Abstract:Adult female rats that underwent sympathectomy induced by guanethidine treatment (10, 20 or 40 mg/kg) exhibited markedly increased water intake, but did not display significant alterations of either food intake, body weight, or the Lee Index of obesity. Guanethidine treatment did not attenuate amphetamine anorexia as evidenced by comparable dose-dependent reductions in food intake to d-amphetamine sulfate (0.25, 0.50, 1.0, and 2.0 mg/kg) in sympathectomized and control rats. These data are not consistent with the hypothesis that amphetamine anorexia is partially mediated via enhanced BAT thermogenesis.
Keywords:Guanethidine  Sympathectomy  Food intake  Hyperdipsia  Amphetamine anorexia  Body weight
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