Acute and Subacute Toxicity of Aspilia Africana Leaves |
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| Authors: | Lienou C Taziebou F-X Etoa B Nkegoum C A Pieme D PD Dzeufiet |
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| Affiliation: | 1Microbiology and Pharmacology Laboratory, Department of Biochemistry, Faculty of Science, P. O. Box 812, University of Yaounde I, Cameroon;2Pathology Laboratory, Faculty of Medicine and Biomedical Sciences, P. O. Box 2787, University of Yaounde I, Cameroon;3Animal Physiology Laboratory, Department of Animal Biology and Physiology, Faculty of Science P. O. Box 812, University of Yaounde I, Cameroon |
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| Abstract: | This study was designed to evaluate the toxicity of the aqueous extract of Aspilia africana leaves. Oral doses of 500 mg/kg and 1000 mg/kg were administered for 28 days to rats after every 2 days for sub-acute toxicity. For acute toxicity, 5 doses of 2, 4, 8, 12 and 16g/Kg body weight were investigated in mice. The control groups consisted of mice or rats administered with distilled water. The signs of toxicity fluctuated lightly from one mammal to another throughout the experiment. The liver, kidneys and heart weight of rats revealed no significant differences between the test groups and the control. The results indicated that the medium lethal dose (LD50) was found to be greater in females than males with an average of 6.6g/Kg body weight for both sexes. Regardless of the significant differences observed at certain points in some biochemical parameters (ALT, AST, ALP, Creatinine and Glutathione); none showed any linear dose responsiveness. On the other hand, most of the parameters investigated were found to be gender dependent. These results suggested that A Africana can be classified among substances with low toxicity. |
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| Keywords: | Aspilia africana Asteraceae toxicities dose responsiveness |
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