Apoptosis Inducing Effect of Andrographolide on TD-47 Human Breast Cancer Cell Line |
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| Authors: | Sukardiman Harjotaruno Aty Widyawaruyanti Sismindari Noor Cholies Zaini |
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| Affiliation: | 1Department of Natural Product Sciences, Faculty of Pharmacy Airlangga University Surabaya Indonesia;2Department Pharmaceutical Chemistry Faculty of Pharmacy Gadjahmada University Yogyakarta, Indonesia |
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| Abstract: | ![]()
Andrographolide isolated from Andrographis paniculata Ness (Acanthaceae) at 0.35 mM, 0.70 mM and 1.40 mM induced DNA fragmentation and increased the percentage of apoptotic cells when TD-47 human breast cancer cell line was treated for 24, 48 and 72 h. The results demonstrated that andrographolide can induce apoptosis in TD-47 human breast cancer cell line in a time and concentration-dependent manner by increase expression of p53, bax, caspase-3 and decrease expression of bcl-2 determined by immunohistochemical analysis. |
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| Keywords: | Andrographis paniculata Ness andrographolide TD-47 cell apoptosis |
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