老年人颈动脉病变与骨质疏松相关性研究

目的 探讨老年人颈动脉病变与骨质疏松的关系. 方法 选择老年患者102例,均经超声检查颅外段颈动脉,测量颈动脉内-中膜厚度(IMT)和计算颈动脉斑块指数(PI),同时检测骨密度(BMD);根据BMD检测结果 分为骨质疏松组和非骨质疏松组,将两组的部分生化指标检测结果 、IMT、PI及颈动脉狭窄率进行比较;用Logistic回归方法 和偏相关法分析有关因素与骨质疏松之间的关系. 结果 两组血钙比较差异有统计学意义(P＜0.01),而两组总胆固醇、三酰甘油、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(HDL-C)比较,差异有统计学意义(均为P＜0.05),但两组血磷、空腹血糖、尿酸比较,差异无统计学意义(P＞0.05);骨质疏松组IMT、PI均高于非骨质疏松组(P＜0.05);102例患者中,检出颈总动脉(CCA)狭窄＞50%的48例,其中骨质疏松组41例,明显高于非骨质疏松组7例(P＜0.05);Logistic回归显示:年龄、HDL-C、IMT、PI、CCA狭窄50%对骨质疏松有影响,其中以IMT、PI、CCA狭窄＞50%的OR值较大(分别为17.13、99.33、289.13),颈动脉病变与骨质疏松之间存在正相关. 结论 老年人骨质疏松与颈动脉病变存在内在相关关系,对于老年患者两种疾病的综合防治值得重视.

Relationship between osteoporosis and carotid artery disease in the elderly

Objective To study the relationship between osteoporosis and carotid artery disease in the elderly. Methods 102 elderly patients were registered for this study and the extraeranial carotid was detected by ultrasound scan. The carotid intima-media thickness (IMT) and the plaque index (PI) were measured and calculated respectively. Meanwhile the patients were divided into two groups according to the results of bone mineral density (BMI) measurement: the osteoporosis group and the non-osteoporosis group. The IMT, PI, carotid stenotic rate and some biochemical parameters were recorded and compared between the two groups. Relationship between these parameters and osteoporosis were evaluated by logistic regression model and partial correlation analysis. Results The differences in serum calcium and the levels of TC,TG,HDL and LDL between osteoporosis group and non-osteoporosis group were statistically significant (all P＜0.05), while the level differences in serum phosphorus, fasting blood glucose and uric acid had no statistical significance between the two groups (P＞0.05). Moreover, the IMT and PI in osteoporosis group were significantly higher than those in non-osteoporosis group (P＜0.05). Among the 102 patients, 48 cases showed the carotid stenotic rate ＞ 50%, including 41 patients in osteoporosis group as well as 7 patients in non-osteoporosis group(P＜0.05). Logistic regression showed that age, HDL-C, IMT, PI and carotid stenotic rate＞50 % were the correlated factors of osteoporosis and among them, IMT, PI and carotid stenotic rate＞50% had higher risks (OR = 17.13,99.33,289.13). There was positive correlation between the carotid artery disease and osteoporosis. Conclusions There is a relationship between osteoporosis and carotid artery disease in the elderly. Emphasis should be paid on comprehensive prevention for osteoporosis and carotid artery disease in the elderly.