高危型HPV阳性患者宫颈支原体和衣原体感染与宫颈组织学改变的关系

目的 探讨高危型HPV阳性不孕患者宫颈支原体和衣原体感染与宫颈组织病变的关系.方法 以HPV阴性不孕患者为对照,回顾分析不同高危型别HPV阳性不孕患者宫颈支原体和衣原体感染与宫颈组织病理分级、炎症分级之间的关系.结果 支原体阳性者HPV感染的发生率与支原体阴性者差异有统计学意义（P＜0.01）,衣原体阳性者HPV感染的发生率与衣原体阴性者差异无统计学意义（P＞0.05）.与HPV阴性组比较,HPV阳性者CIN和宫颈糜烂发生率以及CIN分级均较高（P＜0.01）,HPV阳性者宫颈糜烂程度无差异（P＞0.05）.与单纯HPV阳性组比较,HPV和支原体混合感染者CIN发生率及重度宫颈糜烂无差异（P＞0.05）.结论 支原体感染增加了高危型HPV的感染概率,高危型HPV感染增加了宫颈组织的病理损害程度,支原体感染可能是高危型HPV持续性感染的因素,宫颈组织病理程度是宫颈性不孕不可忽视的因素.

Relationship between mycoplasma and chlamydia infection and lesions in the cervical tissue in high-risk HPV-positive patients

Objective Discussion of the relationship between Mycoplasma and chlamydia infection and lesions in the cervical tissue in high-risk HPV-positive infertile patients with cervical. Methods HPVnegative patients with cervical as the control, retrospective analysis the relationship of Mycoplasma hominis and chlamydia infection, cervical histological graded, and inflammation graded. Results The rate of HPV infection in mycoplasma-positive and those with negative mycoplasma has significant difference (P ＜0.01 ) ,The rate of HPV infection in chlamydia-positive and those with negative chlamydia has no significant difference ( P ＞ 0.05). CIN and the incidence of cervical erosion and CIN grade were higher in HPVpositive than HPV-negative group (P ＜ 0.01 ). The cervical erosion of HPV-positive was no difference in the degree ( P ＞ 0.05). Compared with the simple HPV-positive group, CIN and the incidence of severe cervical erosion in mixed infection of Mycoplasma was no difference (P ＞ 0.05). Conclusion Mycoplasma infection increases the rate of high risk HPV infection, high-risk HPV infection increased cervical pathological damage, Mycoplasma infection might be the factor of persistent infection with high risk HPV,the degree of cervical pathological is the factor of cervical infertility which can not be ignored.