双介入疗法姑息性治疗晚期恶性胰腺肿瘤

目的探索晚期胰腺癌姑息性治疗方法，提高患者生活质量，延长生存时间。方法晚期恶性胰腺肿瘤患者85例，应用Seldingner技术行供血动脉插管介入化疗，并对其中53例消化道梗阻者行腔内支架安置术。结果供血动脉插管介入化疗2个月后复查统计85例中，CR6例，PR46例，无变化29例，肿瘤增大4例，有效率(CR+PR)为61.18%；支架置入者1个月后复查阻塞性黄疸或十二指肠梗阻症状均缓解；全组病例生存时间3～51个月，平均19.5个月。结论双介入疗法姑息性治疗晚期恶性胰腺肿瘤能起到提高生活质量，延长生存期的目的。

Palliative dual interventional therapy for late stage pancreatic malignancies

Aim To explore the efficacy of palliative therapy in late stage pancreatic malignancies so as to improve the quality of life and prolong the survival period. Methods Used the Seldlinger technique through arterial catheterization of the tumor-feeding artery and injected the chemotherapeutic drugs in 85 patients of pancereatic malignancies, and placed intraluminal stent in 53 cases of duodenal or biliary obstruction. Results Among the 85 cases, two months after the interventional therapy, there were 6 CR, 46 PR, no change in 29 cases and tumor enlarged in 4 cases, the total effective rate was 61.18%, One month after the stent placement, the obstructive jaundice and duodenal obstruction were relieved in most of them. The mean survival period was 19.5 months(3-51 months). Conclusion The palliative dual interventional therapy gave rise to improvement of quality of life and prolongation of survival period in late stage pancreatic malignancies.