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| 引用本文： | 庄辉. �������β��ݺ���[J]. 中国实用内科杂志, 2011, 31(2): 81-82 |
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| 作者姓名： | 庄辉 |
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| 作者单位： | 北京大学医学部病原生物学系; |
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| 基金项目： | 国家“863”高技术研究发展计划资助项目(2006AA02Z453); 国家自然科学基金资助项目(30570063) |
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| 摘 要： | 戊型肝炎病毒是散发性和流行性病毒性肝炎的重要病原之一。中国一般人群中约1/3人曾感染过该病毒,主要侵犯中老年人群。虽然戊型肝炎为自限性疾病,一般不发展成慢性肝炎,但其病死率相对较高。戊型肝炎病毒至少有4个基因型,中国流行的是基因1型和4型,基因3型和4型主要见于猪,为人畜共患性疾病。中国自主研制的重组戊型肝炎疫苗(HEV239)随机双盲安慰剂对照Ⅲ期临床试验结果表明,该疫苗在我国普通人群中可有效预防戊型肝炎,且耐受性良好,有望用于高危人群的预防。
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| 关 键 词： | 戊型肝炎 戊型肝炎病毒 基因型 疫苗 |
More attention needed for control of hepatitis E |
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| ZHUANG Hui. More attention needed for control of hepatitis E[J]. Chinese Journal of Practical Internal Medicine, 2011, 31(2): 81-82 |
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| Authors: | ZHUANG Hui |
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| Affiliation: | ZHUANG Hui.Department of Microbiology,Peking University Health Science Center,Beijing 100191,China |
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| Abstract: | Hepatitis E virus is a major cause of sporadic and epidemic viral hepatitis.About one third of the general population in China have been infected with the virus.The disease mainly affects lead to the middle-aged and elderly populations.Although hepatitis E tends to be self-limited and usually does not chronic hepatitis,the mortality of the disease is relatively high.At least four genotypes of hepatitis E viruses have been identified by now.Genotype 1 and 4 are prevalent in China.Genotype 3 and 4 are mainly ... |
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| Keywords: | hepatitis E hepatitis E virus genotype vaccine |
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