Head and neck manifestations of paracoccidioidomycosis: A retrospective study of histopathologically diagnosed cases in two medical centers in southern Brazil |
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| Authors: | Alessandra Koehler Fábio Muradás Girardi Leo Kraether Neto Paulo Cezar de Moraes Vilmar Fontanive Junior Maria Lúcia Scroferneker |
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| Affiliation: | 1. Postgraduate Program in Medicine: Medical Sciences, Universidade Federal do Rio Grande do Sul. Porto Alegre RS, Brazil;2. Integrated Oncology Center, Hospital Ana Nery. Santa Cruz do Sul - RS, Brasil;3. School of Dentistry and Oral Diagnostic Project, Universidade de Santa Cruz do Sul. Santa Cruz do Sul - RS, Brasil;4. Respiratory Department of Instituto de Cardiologia Fundação, Universitária de Cardiologia (IC-FUC). Porto Alegre RS, Brasil;5. Department of Microbiology, Immunology and Parasitology, Universidade Federal do Rio Grande do Sul. Porto Alegre RS, Brazil;1. Outpatient clinic for cutaneous manifestations of primary immunodeficiencies in the dermatology department of Hospital das Clinicas, Faculty of Medicine, University of São Paulo. São Paulo, Brazil;2. Adjunct Professor of Clinical Mycology and Supervised Internship at State University of Centro-Oeste (UNICENTRO-Paraná);1. Division of Infectious Diseases, Department of Internal Medicine, Thammasat University, Pathum Thani Province, Thailand;2. Chulabhorn International College of Medicine, Thammasat University, Pathum Thani Province, Thailand;3. Department of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, Thailand;4. American Regent, Norristown, PA, USA;1. Department of Microbiology, General Hospital of Nikaia Agios Panteleimon, Athens, Greece;2. Clinical Microbiology Laboratory, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece;3. Neonatal Intensive Care Unit, General Hospital of Nikaia Agios Panteleimon, Athens, Greece;4. Department of Microbiology, Metaxa Memorial Anticancer Hospital of Piraeus, Greece;1. Department of Bacteriology, University Hospital of Dijon, BP 37013, 21070 Dijon CEDEX, France;2. UMR/CNRS 6249 Chrono-environnement, University of Bourgogne-Franche-Comté, Besançon, France;3. Laboratoire de Parasitologie-Mycologie, Plateforme de Biologie Hospitalo-universitaire, 2 rue A. Ducoudray, BP 37013, 21070 Dijon Cedex, France;4. UMR PAM Univ Bourgogne Franche-Comté - AgroSup Dijon - Equipe Vin, Aliment, Microbiologie, Stress, 21078 Dijon, cedex, France;1. Department of Microbiology, Tata Medical Center, Kolkata, India;2. Department of Pediatric Oncology, Tata Medical Center, Kolkata, India;1. Microbiology Department, Parasitology-Mycology Unit, Faculty of Medicine, Paris University, AP–HP, European Georges-Pompidou Hospital, 75015 Paris, France;2. Microbiology Department, Parasitology-Mycology Unit, Faculty of Medicine, Paris University, Necker-Enfants Maladies Hospital, 75015 Paris, France;3. Medical Intensive Care Unit, Faculty of Medicine, Paris-Descartes University, AP–HP, European Georges-Pompidou Hospital, 75015 Paris, France;4. Fungal Biology and Pathogenicity. Institut Pasteur, Paris, France;5. Dynamyc EA 7380, Paris-Créteil University, Créteil, France |
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| Abstract: | BackgroundParacoccidoidomycosis (PCM) is a granulomatous systemic mycosis endemic in southern Brazil.ObjectivesAnalyze the clinical and epidemiological characteristics of cases of PCM with head and neck manifestations in southern Brazil.Material and methodsRetrospective study of histopathologically diagnosed cases of PCM with head and neck manifestations referred to two medical centers in the municipality of Santa Cruz do Sul, state of Rio Grande do Sul, Brazil, during a 10-year period (2011–2020).ResultsTwenty-eight patients were selected. The number of cases usually ranged from one to four per year, although 11 cases were diagnosed in 2019. Most patients were between 40 and 59 years old. In total, 21 patients were men and seven were women (male:female ratio 3:1). Most (92%) were Caucasian and 46% were smokers. Patients were from 12 municipalities in the central-eastern region of the state. The most frequent site of the lesions was the larynx. Associated HIV and squamous cell carcinoma were both present in three cases.ConclusionsThis is the first study to analyze PCM cases from central-eastern Rio Grande do Sul. PCM is endemic in southern Brazil, and more epidemiological data are needed, considering that its incidence may be higher than currently estimated, as demonstrated by our results. |
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| Keywords: | Paracoccidioidomycosis Epidemiology Systemic mycosis Head and neck |
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