First case of endophthalmitis by Corynespora cassiicola |
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| Authors: | Parakriti Gupta Atul Arora Mantavya Gupta Ramandeep Singh Shivaprakash M Rudramurthy Harsimran Kaur |
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| Institution: | 1. Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India;2. Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India;3. Precise Healthcare Clinical Laboratory, Sector 30, Chandigarh;1. Department of Bacteriology, University Hospital of Dijon, BP 37013, 21070 Dijon CEDEX, France;2. UMR/CNRS 6249 Chrono-environnement, University of Bourgogne-Franche-Comté, Besançon, France;3. Laboratoire de Parasitologie-Mycologie, Plateforme de Biologie Hospitalo-universitaire, 2 rue A. Ducoudray, BP 37013, 21070 Dijon Cedex, France;4. UMR PAM Univ Bourgogne Franche-Comté - AgroSup Dijon - Equipe Vin, Aliment, Microbiologie, Stress, 21078 Dijon, cedex, France;1. Division of Infectious Diseases, Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, Manhasset, New York 11030, USA;2. Department of Cardiovascular and Thoracic Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, Manhasset, New York 11030, USA |
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| Abstract: | Corynespora cassiicola is an environmental phytopathogen implicated in various human infections and has been isolated from one case of keratitis. We report here the first case of endophthalmitis caused by Corynespora cassiicola in a 54-year-old diabetic patient, who developed diminished vision, redness, and watering in the right eye, six weeks after intravitreal triamcinolone acetonide for non-proliferative diabetic retinopathy and macular oedema. Direct microscopy of the vitreous tap revealed septate hyphae, and culture grew white mycelium that turned olive-grey to black within two days and was confirmed as C. cassiicola after sequencing of the ITS region of 28S rDNA. The patient was started on oral voriconazole 200 mg twice a day. The patient is on regular follow-up without recurrence. To our knowledge, this case represents the first case of endophthalmitis due to this fungus across the globe and the first case of C. cassiicola infection from India. |
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| Keywords: | Corynespora Endophthalmitis India Diabetes |
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