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| 白藜芦醇和抗坏血酸对预防非典型肺炎方剂Ⅰ和Ⅵ所致小鼠外周血液淋巴细胞DNA损伤的保护作用 | |
| 引用本文： | 金顺姬,段链,黄梅,杨静玉,于海,赵余庆,吴春福. 白藜芦醇和抗坏血酸对预防非典型肺炎方剂Ⅰ和Ⅵ所致小鼠外周血液淋巴细胞DNA损伤的保护作用[J]. 中草药, 2003, 34(12): 1114-1117 |
| 作者姓名： | 金顺姬 段链 黄梅 杨静玉 于海 赵余庆 吴春福 |
| 作者单位： | 1. 沈阳药科大学,药理教研室,辽宁,沈阳,110016 2. 辽宁中医学院新药研究中心,辽宁,沈阳,110000 |
| 摘 要： | 目的研究白藜芦醇和抗坏血酸对预防非典型肺炎方剂Ⅰ和Ⅵ致小鼠外周血液淋巴细胞DNA损伤的保护作用.方法采用单细胞凝胶电泳方法研究白藜芦醇和抗坏血酸对预防非典型肺炎方剂Ⅰ和Ⅵ致小鼠外周血液淋巴细胞DNA损伤的保护作用.结果白藜芦醇(50,100,200 mg/kg×3 d)和抗坏血酸(50,100,200 mg/kg×3 d)对方剂Ⅰ和Ⅵ(临床等效量×3 d)所致的小鼠外周血液淋巴细胞DNA损伤呈剂量依赖性的保护作用(P＜0.05).结论白藜芦醇和抗坏血酸能够保护预防非典型肺炎方剂J和Ⅵ对小鼠外周血液淋巴细胞DNA的损伤. |
| 关 键 词： | 白藜芦醇 抗坏血酸 预防非典型肺炎方剂 DNA损伤 单细胞凝胶电泳 |
| 收稿时间： | 2003-07-17 |
Protective effect of resveratrol and ascorbic acid on lymphocyte DNA damage in mice induced by prescriptions Ⅰ and Ⅵ of Chinese materia medica against SARS |
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| JIN Shun ji,DUAN Lian,HUANG Mei,YANG Jing yu,YU Hai,ZHAO Yu qing and WU Chun fu. Protective effect of resveratrol and ascorbic acid on lymphocyte DNA damage in mice induced by prescriptions Ⅰ and Ⅵ of Chinese materia medica against SARS[J]. Chinese Traditional and Herbal Drugs, 2003, 34(12): 1114-1117 | |
| Authors: | JIN Shun ji DUAN Lian HUANG Mei YANG Jing yu YU Hai ZHAO Yu qing WU Chun fu |
| Affiliation: | Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China;Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China;Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China;Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China;Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China;Research Center of New Drug, Liaoning College of TCM, Shenyang 110000, China;Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China |
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