hs-CRP在急性脑梗死患者动态水平及预后的临床意义

目的：观察超敏C-反应蛋白（hs-CRP）在脑梗死患者的动态水平与其病情预示作用，了解hs-CRP同脑梗死患者病情关系。方法：收集126例脑梗死患者发病后72h内，第（4—7）d和第14d的血清进行超敏免疫比浊法测定hs-CRP。应用美国国立卫生研究院卒中量表（NIHSS）及Barthel指数（BI）记分法测定神经功能缺损评分。结果：脑梗死后72h血清hs-CRP浓度即开始升高，1周左右达高峰，至14d时接近对照组水平，并发多脏器功能衰竭者CRP水平最高。结论：hs—CRP是判断脑梗死病情轻重和预后的特异性指标，适时终止或减轻炎症反应损害，可以降低脑梗死的病死率及并发多脏器衰竭的危险。

Clinical Significance of Dynamic Changes of Serum Hypersensitive C Reactive Protein (HS-CRP) Concentrations in Patients with Acute Cerebral Infarction

Objective To investigate the prognostic meanings of dynamic changes of serum hs-CRP levels in patients with acute cerebral infarction. Methods Plasma hs-CRP levels were determined with immune turbidimetry in 126 patients was determined dynamically within 72h after onset, at seventh day and at fourteenth day. The nerve inpairment score was determined with NIHSS and BI method. Results Plasma CRP concentrations began rising within 72h after cerebral infarction, would reach the peak at about one week and would approach the level of control group at the fourteenth day. The CRP levels in patients with concurrent multipleorgan failure were the highest. Conclusion Plasma CRP could be used as specific indicator of sverity of the disease process.