血必净注射液对全身炎症反应综合征患者C-反应蛋白及D-二聚体的影响

目的通过测定血必净注射液对全身炎症反应综合征患者C-反应蛋白（CRP）及D-二聚体（D—Dimer）的变化探讨其在阻断全身炎症反应综合征（SIRS）向多器官功能障碍综合征（MODS）发展的作用。方法72例患者随机分为治疗组36例和对照组36例。对照组常规接受抗感染补液治疗，治疗组在对照组常规治疗基础上静脉注射m必净100mL，12h1次，连用7d，在常规监测患者心率、呼吸频率、体温、血常规的基础上再重点监测CRP、D—Dimer及SIRS症状改善时间及MODS的发生率。结果治疗组CRP及D—Dimer下降明显快于对照组．SIRS改善情况明显优于对照组（P〈0．05），转为MODS患者较对照组明显减少（P〈0．05）。结论血必净注射液能明显改善SIRS症状，降低SIRS患者CRP、D—Dimer，调控机体炎症反应过程，阻断SIRS患者向MODS的发展。

Effect of Xuebijing injection on C-reactive protein and D-dimer of patients with systemic inflammatory response syndrome

Objective To explore the effect of Xuebijing injection on blocking systemic inflammatory response syn- drome（SIRS） to the development of multiple organ dysfunction syndrome （MODS） by the determination of changes of C-reactive protein （CRP） and D-dimer of patients with SIRS. Methods Seventy-two patients were randomly divided into the treatment group and the control group, and each group had 36 cases. The patients in the control group re- ceived conventional rehydration anti-infection treatment, while on the basis of conventional treatment, the patients in the treatment group were treated with the intravenous injection of 100 mL Xuebijing injection, one time every 12 hours and even for 7 days. The CRP, D-dimer and symptom improvement time of SIRS and incidence of MODS of patients were monitored mainly on the basis of routine monitoring of heart rate, respiratory frequency, body temperature and blood routine. Results Compared with the control group, the CRP and D-dimer in the treatment group decreased sig- nificantly, SIRS improved significantly （P 〈 0.05）, number of cases to MODS reduced significantly （P 〈 0.05）. Conclu- sion Xuebijing injection can obviously improve the symptoms of SIRS, decrease the CRP, D-dimer of patients with SIRS, control the inflammatory reaction and block the patients with SIRS to the development of MODS.