高压氧治疗成人出血型烟雾病的疗效分析和风险评估

目的 观察高压氧治疗成人出血型烟雾病的疗效分析和治疗相关风险评估。方法 统计2010-2015年收治以脑出血为表现的成人出血型烟雾病患者41例，根据治疗方案分为高压氧组21例和常压氧组20例，应用改良Rankin量表（modified Rankin Scale，mRS）等量表对发病后90 d患者的神经功能进行评价，比较两组的疗效及治疗相关风险。应用Logistic回归分析影响疗效的因素。结果 高压氧组发病90 d mRS评分低于对照组（P =0.003）。多因素Logistic回归分析显示高压氧治疗次数是高压氧组疗效的影响因素（OR 0.790，95%CI 0.681～0.903，P =0.001)。结论 高压氧治疗成人出血型烟雾病有效且安全，治疗次数是影响高压氧疗效的因素。

Effect Analysis and Risk Evaluation of Hyperbaric Oxygen Therapy on Hemorrhagic Moyamoya Disease in Adult

Objective To investigate the effect of hyperbaric oxygenation therapy (HBOT) after hemorrhagic-type Moyamoya disease (hMMD) in adult and treatment-related risk factors. Methods A total of 41 adult patients with hMMD admitted from 2010 to 2015 were prospectively studied. The patients were divided into HBOT group (21 cases) and control group (20 cases). Modiifed Rankin Scale (mRS) of neurologic assessments were performed on the 90th day after onset. The effects and related risks of two groups were compared. Logistic regression analysis was used to analyze the risk factors of treatment effect. Results mRS of the 90th day after onset in the HBOT group was lower than the control group (P=0.003). The multivariate Logistic regression analysis showed that the risk factor associated with treatment effect in the HBOT group was frequency of HBOT (OR 0.790, 95%CI0.681-0.903,P=0.001). Conclusion HBOT is effective and safe after Moyamoya disease. Frequency of HBOT is the factor to inlfuence on the treatment effect.