原发性肝癌中医临床用药荟萃分析

目的:探讨原发性肝癌中医临床用药规律,为临床用药提供启示。方法:建立原发性肝癌中医临床用药的数据库,对中医临床用药归类、用药频次和用药剂量进行聚类分析。结果:补虚药为最常用药,清热药、活血化瘀药、利水渗湿药和理气药为较常用药;解表药和消食药为常用药;单味药用药频率第1位的是白术、茯苓、党参,单味药总体用药剂量偏大;常用经典方有四君子汤、小柴胡汤、一贯煎、香砂六君子汤、逍遥丸、膈下遂淤汤、六味地黄汤、茵陈蒿汤等。鸡内金、麦芽为治疗纳呆食少的最常用药;黄芪为治疗神疲乏力的最常用药;元胡、川楝子为治疗肝区疼痛的最常用药;大腹皮、猪苓、茯苓为治疗腹水的最常用药;茵陈蒿为治疗黄疸的最常用药。结论:益气健脾、疏肝理气、清热利湿、活血化瘀、滋阴解毒为中医治疗肝癌的主要原则。改善临床症状体征,改善患者的生存质量的治疗也是中医临床治疗的关键。

Regularity analysis on clinical treatment in primary liver cancer by traditional Chinese medicine

Objective: To evaluate clinical treatment regularity of traditional Chinese medicine(TCM) on primary liver cancer and provide inspiration for the clinical use. Method: Traditional Chinese medicine database on primary liver cancer was established to analysis the classification, frequency, dosage of TCM in clinical treatment. Result: Tonic medicine is the most common medication, herbs for heat-clearing, promoting blood circulation for removing blood stasis, eliminating dampness and diuresis and regulating flow of Qi are more common medication, herbs for relieving exterior disorder and digesting are common medication; the first frequency of single herb is Atractglodis Macrocephalae Rhizoma, Poria, Codonopsis Radix. Popular classical prescriptions are Sijunzi Tang, Xiaochaihu Tang, YiguanJian, Xiangsha Liujunzi Tang, Xiaoyao Wan and Gexia Zhuyu Tang, Liuwei Dihuang Tang and Yinchenhao Tang et al.Gallic Gigerii Endothelium Corneum and Ophiopogonis Radix are most commonly drug for poor appetite. Astragali Radix is most commonly drug for fatigue. Corydalis Rhizoma, Toosendan Fructus are most common for liver pain; Pericarpium Arecae, Polyporus, Poria are most common herbs for ascites; Artemisiae Scopariae Herba is common drug for jaundice. Conclusion: Replenishing qi to invigorate the spleen, sparsing liver to regulate the flow of vital energy, clearing heat and promoting diuresis, promoting blood circulation for removing blood stasis, nourishing yin and detoxification are the main principles for treating primary liver cancer. Improving clinical symptoms, signs and quality of life of patients with TCM is the key to clinical treatment.