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| 藏药甘青乌头化学成分的研究 | |
| 引用本文： | 罗明,林丽美,李春,王智民,郭五保.藏药甘青乌头化学成分的研究[J].中国中药杂志,2012,37(9):1245-1248. |
| 作者姓名： | 罗明 林丽美 李春 王智民 郭五保 |
| 作者单位： | 1. 陕西中医学院,陕西咸阳712046;中国中医科学院中药研究所,北京100700;中药质量控制技术国家工程实验室,北京100700 2. 湖南中医药大学,湖南长沙,410208 3. 中国中医科学院中药研究所,北京100700;中药质量控制技术国家工程实验室,北京100700 4. 陕西中医药研究院实验中心,陕西西安,710003 |
| 基金项目： | 国家"重大新药创制"科技重大专项(2009ZX09301-005,2009ZX09308-003) |
| 摘 要： | 目的:研究藏药甘青乌头Aconitum tanguticum的化学成分.方法:采用硅胶,SephadexLH-20凝胶,ODS,制备液相等多种色谱技术进行化合物的分离纯化,通过多种波谱分析方法鉴定化合物结构.结果:从甘青乌头大极性部位分离鉴定了7个化合物,分别为山柰酚-3-O-α-L-鼠李糖基-(1→6)-β-D-半乳糖苷]-7-O-α-L-鼠李糖苷(1),山柰酚-3-O-α-L-鼠李糖基-(1→6)-β-D-葡萄糖苷] -7-O-α-L-鼠李糖苷(2),山柰酚-7-O-α-L-鼠李糖苷(3),龙胆苦苷(4),吐叶醇-9-O-β-D-葡萄糖苷(5),二氢吐叶醇-9-O-β-D-葡萄糖苷(6),3,4-二羟基-苯乙醇-β-D-葡萄糖苷(7).结论:所有化合物均为首次从该植物中分离得到. |
| 关 键 词： | 甘青乌头 黄酮 化学成分 |
| 收稿时间： | 1/5/2012 12:00:00 AM |
Chemical constituents of Aconitum tanguticum |
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| LUO Ming,LIN Limei,LI Chun,WANG Zhimin and GUO Wubao.Chemical constituents of Aconitum tanguticum[J].China Journal of Chinese Materia Medica,2012,37(9):1245-1248. | |
| Authors: | LUO Ming LIN Limei LI Chun WANG Zhimin and GUO Wubao |
| Institution: | Shaanxi University of Traditional Chinese Medicine, Xianyang 712046,China; Institute of Chinese Materia Medica, China Academy of Chinese Medicine Sciences, Beijing 100700, China; National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines, Beijing 100700, China;Hunan University of Traditional Chinese Medicine, Changsha 410208, China;Institute of Chinese Materia Medica, China Academy of Chinese Medicine Sciences, Beijing 100700, China; National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medicine Sciences, Beijing 100700, China; National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines, Beijing 100700, China;Experimental Center of Shaanxi Academy of Traditional Chinese Medicine, Xi'an 710003, China |
| Abstract: | Objective:To study the chemical constituents isolated from the whole plant of Aconitum tanguticum.Method:Chemical constituents were isolated and purified from the title plant by using a combination of various chromatographic techniques including column chromatography over silica gel,Sephadex LH-20,ODS and preparative HPLC.Their structures were elucidated by spectroscopic techniques including 1H-NMR,13C-NMR,2D-NMR,and ESI-MS.Result: Seven compounds were isolated from this plant and their structures were identified as kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-galactopyranoside]-7-O-α-L-rhamnopyranoside(1),kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside]-7-O-α-L-rhamnopyranoside(2),kaempferol 7-O-α-L-rhamnopyranoside(3),gentiopicroside(4),vomifoliol-9-O-β-D-glucopyranoside(5),dihydrovomifoliol-9-O-β-D-glucopyranoside(6) and 3,4-dihydroxyphenyl alcohol-β-D-glucopyranoside(7).Conclusion: All the compounds were isolated from this plant for the first time. |
| Keywords: | Aconitum tanguticum flavonoids chemical constituents |
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