以勿动蛋白-A及其受体为靶点的促神经再生中药研究

查阅相关数据库文献38篇,整理和分析了中药对勿动蛋白-A( Nogo-A)及勿动蛋白受体(NsR,Nogo receptor)调节作用的研究.探讨Nogo-A及NgR这2个药物靶点相关的中枢神经系统(CNS)损伤修复中药的研究进展.基于对Nogo-A的表达分布和功能作用,Nogo-A单克隆抗体与NgR拮抗剂的认识,进一步了解CNS损伤修复的机制,对于中枢神经系统再生障碍的药物治疗有重要的临床意义.中药可以诱导CNS产生有利的微环境促进神经再生.Nogo-A及NgR的表达可抑制神经的发生,中药可抑制其表达从而发挥神经保护的作用.但Nogo-A在脑损伤治疗中的研究还处于基础阶段,使用中药(髓复康、首乌仙海片、血塞通、三七三醇皂苷、逍遥散、补阳还五汤、左归丸和右归丸等)调节Nogo-A及其受体NgR的表达少见报道,机制未明.故探讨Nogo-A及NgR作为药物开发靶点的潜在价值,为今后中药临床治疗该靶点相关的疾病及促神经再生中药新药研发提供一定的参考.

Nogo-A and Its Receptor in Promoting Nerve Regeneration and Intervention of Traditional Chinese Medicine

Study Nogo-A and its receptor NgR (Nogo receptor) in promoting nerve regeneration and the intervention of traditional Chinese medicine(TCM),to find out the progress of TCM in repairing impaired central nervous system(CNS) that related to drug targets of Nogo-A and NgR. Based on the understanding of the expression and function of Nogo-A, the Nogo-A monoclonal antibody and the NgR antagonist, understanding more about the mechanism of repairing damaged CNS had an important clinic significance for the drug in treating neurite outgrowth inhibition following CNS injury. TCM can induce CNS produced beneficial micro-environment to promote nerve regeneration. The intervention of TCM can inhibit the expression of Nogo-A and NgR that can inhibit the occurrence of nervous. But Nogo-A in the research of the treatment of brain damage is still in the basic stage, reports on using TCM (Suifukang, Shouwuxianhai tablet, Sanqi Panax Notoginseng, Panaxtriol saponins, Xiaoyao powder, Buyang Huanwu decoction, Zuogui pill, and Yougui pill, etc.)to regulate the expression of Nogo-A and its receptor are few, the mechanisms are unknown.Therefore discussing the potential value of drug development and targets of Nogo-A and NgR is necessary. This review is providing a reference to TCM used in clinical treatment of diseases that are bound up with targets of Nogo-A and NgR, and new drug research and development of TCM that promote nerve regeneration in the future.