Feline CD 4 molecules expressed on feline non-lymphoid cell lines are not enough for productive infection of highly lymphotropic feline immunodeficiency virus isolates |
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| Authors: | J. Norimine T. Miyazawa Y. Kawaguchi K. Tomonaga Y. -S. Shin T. Toyosaki M. Kohmoto M. Niikura Y. Tohya T. Mikami |
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| Affiliation: | (1) Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, Bunkyo-ku, Tokyo, Japan;(2) Present address: Department of Virology, Faculty of Veterinary Science, National University of La Plata, La Plata, Argentina |
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| Abstract: | Summary To investigate whether the feline CD 4 (fCD 4) molecules are involved in infections of highly lymphotropic feline immunodeficiency virus (FIV) isolates, we expressed fCD 4 stably on Crandell feline kidney cells andFelis catus whole foetus 4 cells by transfection of a cDNA encoding the fCD 4 glycoprotein, and then infected them with TM 1 and TM 2 strains of FIV, which are unable to infect these cells productively. In spite of fCD 4 being expressed on these cells, no virus production was observed. This result indicates that fCD 4 expression alone cannot induce a productive infection of the FIV TM 1 and TM 2 strains. |
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