铜绿假单胞菌耐药性监测研究

目的:观察和监测铜绿假单胞菌对常用抗生素的耐药变化,为临床合理使用抗生素提供依据。方法:连续检测2002年至2004年本院铜绿假单胞菌的耐药状况。药敏试验采用K-B纸片法,判定标准依据美国国家临床实验室标准化委员会(NCCLS)标准。结果:铜绿假单胞菌对常用抗生素的耐药率有逐年升高趋势;对铜绿假单胞菌保持较高活性且耐药率<20%的抗生素有阿米卡星、亚胺培南、头孢哌酮/舒巴坦、头孢吡肟、环丙沙星。结论:铜绿假单胞菌对常用抗菌药物的耐药率较高,对铜绿假单胞菌感染的治疗,可首选阿米卡星、头孢哌酮/舒巴坦、亚胺培南、头孢吡肟、环丙沙星等。

Surveillance of Antimicrobial Resistance of Pseudomonas Aeruginosa During

Objective A surveillance study was performed in Pseudomonas aeruginosa to investigate the change of antimicrobial resistance,so as to provide basis for clinical antibiotic selection.Methods K-B test was used for the antibiotics susceptibility test and the results were read based on National committee for Clinical Laboratory standards(NCCLs).Results The drug resistance rates of P.aeruginosa were increased rapidly by years.Those antibiotics such as amikacin、imipenem、cefoperazone/sulbactam、cefepime、ciprofloxacin were very effective to P.aeruginosa with the drug-resistant rate below 20%.Conclusion P.aeruginosa is drug-resistant to common antibiotics.With the patient infected by P.aeruginosa,it should be first treated experientially by amikacin、imipenem、cefepime、cefoperazone/sulbactam、ciprofloxacin,et al.