Comparative analysis of the effects of adapromine, midantane, and bromantane on bioelectrical activity of rat brain

The adamantane derivatives adapromine, midantane, and bromantane modify bioelectrical activity of brain cortex and subcortical structures. Neurophysiological effects of these preparations indicate that they possess psychostimulating activity. The effect of bromantane on electrical potentials from left and right sensorimotor cortex, dorsal hippocampus, and lateral hypothalamus was stronger than that of adapromine and midantane. This effect was observed as greater quantitative changes in the characteristics of electroencephalogram and changes practically in all characteristics of the power spectrum of electroencephalogram. Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 2, pp. 175–179, February, 1998