PTEN及p27在子宫内膜腺癌中的表达及临床意义

目的　研究 PTEN及 p2 7蛋白在子宫内膜腺癌中的表达及临床意义。方法　应用免疫组化法检测 11例正常增生期内膜、4 4例子宫内膜增生症及 5 2例子宫内膜腺癌 PTEN及 p2 7蛋白表达。结果　 PTEN及 p2 7蛋白在正常增生期内膜、子宫内膜简单型 /复杂型增生过长 (无不典型增生 )、子宫内膜不典型增生过长及子宫内膜腺癌中表达率分别为 10 0 .0 %、91.4 %、6 6 .7%、6 7.3%和 90 .9%、88.6 %、6 6 .7%、5 9.6 %。子宫内膜腺癌 PTEN及 p2 7蛋白表达率明显低于正常增生期内膜和简单型 /复杂型增生过长 ( P<0 .0 1) ,与不典型增生过长相比差异无显著性( P>0 .0 5 )。 PTEN及 p2 7蛋白表达随组织分化越差呈递减趋势 ,PTEN表达与子宫内膜腺癌差分化相关 ( P<0 .0 5 ) ,与其它临床病理因素无关。在子宫内膜腺癌中 PTEN及 p2 7蛋白表达有相关性 ( P=0 .0 19)。结论　 PTEN及 p2 7在子宫内膜腺癌发生、发展中起重要作用 ,并可能是子宫内膜腺癌发生中的早期事件 ,检测 PTEN及 p2 7蛋白表达有助于子宫内膜腺癌的早期诊断及预后判断

Expression and clinical significance of PTEN and p27 in endometrial adenocarcinomas of uterus

Objective To study the expression and clinical significance of PTEN(phosphatase and tension homolog deleted on chromosome ten) and p27 in endometrial adenocarcinomas of uterus Methods The expression of PTEN and p27 was detected with S P immmunohistochemistry method in 11 cases of normal endometrium,44 cases of endometrial hyperplasia and 52 of endometrial adenocarcinomas Results The expression rates of PTEN and p27 in normal endometrium, simple/complex hyperplasia (without atypia), atypia hyperplasia and endometrial adenocarcinoma were 100%, 91 4%, 66 7%, 67 3% and 90 9%, 88 6%, 66 7%, 59 6%, respectively The expression of PTEN and p27 in endometrial adenocarcinomas was much lower than that in normal endometrium and simple/complex hyperplasia without atypia ( P <0 01). The rate of the expression of PTEN and p27 decreased from well differentitation to poor differentitation There was a significant correlation of the PTEN expression with poor differentitation ( P <0 05), but not with other clinical pathological parameters ( P >0 05) The expression of PTEN was associated with that of p27 in endometrial adenocarcinomas ( P =0 019) Conclusion The expression of PTEN and p27 may play an important role in carcinogenesis and development of endometrial adenocarcinomas The detection of PTEN and p27 may be helpful for early diagnosis and prognosis of endimetrial adenocarcinama