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| 大肠癌中聚(腺苷二磷酸核糖)水解酶对聚(腺苷二磷酸核糖)聚合酶的调节作用及意义 | |
| 引用本文： | 李佳,林玲,王娅兰. 大肠癌中聚(腺苷二磷酸核糖)水解酶对聚(腺苷二磷酸核糖)聚合酶的调节作用及意义[J]. 第三军医大学学报, 2009, 31(5) |
| 作者姓名： | 李佳 林玲 王娅兰 |
| 作者单位： | 重庆医科大学基础医学院病理学教研室,重庆,400016 |
| 摘 要： | 目的 初步探讨人肠癌中聚(腺苷二磷酸核糖)水解酶[Poly(ADP-ribose)glycohydrolase,PARG]与聚(腺苷二磷酸核糖)聚合酶[Poly(ADP-ribose)polymerase,PARP]的关系.方法 应用S-P免疫绀化检测人大肠癌组织中PARG、PARP的表达;以PARG抑制剂丹宁酸(Gallotannin,GLTN)为处理因索,采用流式细胞计数检测小鼠结肠腺癌CT26细胞中PARG、PARP表达变化.结果 PARG和PARP在人大肠癌组织中的表达呈正相关(γ=0.300 01,P<0.05);流式细胞计数显示,用GLTN处理后,小鼠结肠腺癌CT26细胞中PARG、PARP的阳性细胞率分别较对照组降低,差异具有统计学意义(P<0.05).结论 大肠癌中PARG和PARP的表达有相关性,PARG抑制剂可以抑制PARG及PARP表达,PARG叮能对PARP具有调节作用. |
| 关 键 词： | 聚(腺苷二磷酸核糖)水解酶 聚(腺苷二磷酸核糖)聚合酶 大肠癌 |
Regulatory effects of PARG on PARP in colorectal carcinoma |
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| LI Jia,LIN Ling,WANG Ya-lan. Regulatory effects of PARG on PARP in colorectal carcinoma[J]. Acta Academiae Medicinae Militaris Tertiae, 2009, 31(5) | |
| Authors: | LI Jia LIN Ling WANG Ya-lan |
| Affiliation: | LI Jia,LIN Ling,WANG Ya-lan(Department of Pathology,Chongqing Medical University,College of Basic Medical Sciences,Chongqing 400016,China) |
| Abstract: | Objective To study the relationship between Poly(ADP-ribose) glycohydrolase(PARG) and Poly(ADP-ribose) polymerase(PARP) in colorectal carcinoma.MethodsImmunohistochemical S-P staining was used to examine the expressions of PARG and PARP in 44 specimens human colorectal carcinoma.The positive rate of PARG and PARP in murine colon carcinoma CT26 cells was detected by flow cytometry before and after the treatment of PARG inhibitor Gallotannin.ResultsPARG and PARP expressed in colorectal carcinoma specimens was... |
| Keywords: | Poly(ADP-ribose) glycohydrolase Poly(ADP-ribose) polymerase colorectal carcinoma |
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