老年人急性髓细胞白血病不同剂量化疗疗效观察

目的探讨老年人急性髓细胞白血病，不同化疗剂量的疗效。方法30例患者采用DAE和HAE方案联合化疗，分为中剂量及小剂量组各15例。观察其缓解率、生存时间。结果两组总有效率73．3，CR率467％，PR267％。中剂量组CR9例（60．0％），均CR时间10．3月，平均生存时间11．7月，平均生存时间12．7月；PR6例（40．0％），平均生存时间7．3月。结论对老年白血病患治疗应个体化，一般情况好者应在强有力的支持治疗下，采用中等剂量化疗，相反宜小剂量化疗。

Observation of chemotherapy regimens of different doses for the treatment of acute myeloid leukemia in eledrly patients

Objective To observe the effect of combined chemotherapy regimens of different doses for the treatment of acute myeloid leukemia in elderly patients. Methods 30 patients were treated with combined chemotherapy regimens of DA and HA. The patients were divided into two groups in accordance with the doses they received:the intermediatedose group and the low-dose group. Results The treatment of both groups resulted in a total effective rate of 73. 3% with CR 46. 7% and PR 26. 7 %. In the intermediate-dose group, 9 of 15 patients (60% ) achieved CR and 2 (13. 3% ) reached PR. In the low-dose group, 5 of 15 patients (33. 3 % )achieved CR and 6 (40% ) reached PR. Conclusion The Treatment for the elderly with acute myeloid leukemia should be applied in consideration of different individuals. Tothose with good general physique,intermediate-dose chemotherapy should be applied together with strong suportativetreatment. Otherwise,low-dosage chemotherapy should be applied.