葡萄糖转运蛋白-1在血管瘤和血管畸形中的表达及其意义

目的检测葡萄糖转运蛋白-1(glucose transporter-1,Glut1)在血管瘤和血管畸形组织中的表达并探讨其意义。方法各阶段婴幼儿血管瘤标本52例、海绵状静脉畸形25例、动静脉畸形9例、毛细血管畸形2例、正常皮肤软组织5例。应用En Vision法免疫组化染色检测Glut1在上述标本中的表达。结果增生早期,较多血管瘤内皮细胞表达Glut1;增生中期,绝大部分微血管内皮细胞和散在分布的内皮细胞表达Glut1;增生晚期,Glut1表达迅速减弱;消退期血管瘤微血管内皮细胞不表达Glut1。所有海绵状静脉畸形、动静脉畸形、毛细血管畸形、正常皮肤软组织中的小动静脉和微血管均不表达Glut1。结论Glut1是血管瘤内皮细胞发展过程中的一种表型,而不是其固有特征,Glut1表达是血管瘤内皮细胞适应代谢需要而产生的。

The expression and role of glucose transporter-1 in infantile hemangioma

Objective To investigate the expression and role of glucose transporter-1(Glut1) in infantile hemangioma. Methods Fifty-two samples from infantile hemangioma, 25 in cavernous venous malformation, 9 in arteriovenous malformation, 2 in capillary malformation and 5 in normal skin samples were involved in this study. The EnVision immunohistochemical stain was used to investigate the expression of Glut1 protein in these samples. Results In the early proliferating stage, a number of endothelial cells expressed Glut1. In the middle proliferating stage, most of vascular endothelial cells and scattered endothelial cells expressed Glut1. In the late proliferating stage, the expression of Glut1 decreased quickly. In the involuting stage, all hemangioma samples didn't express Glut1. All of the samples from the cavernous venous malformations, arteriovenous malformations, capillary malformations and normal skin had no expression of Glut1. Conclusions Glut1 may be one of the phenotypes of infantile hemangioma endothelial cells in their development, rather than the inherent character. The expression of Glut1 changes according to the metabolic need of infantile hemangioma cells.