Diagnostic Criteria for Human Diffuse M a lignant Mesothelioma

Diffuse malignant mesothelioma is a rare tumor in the general population, yet is unique in that it is caused almost exclusively by exposure to asbestos with long-term latency (15 years and over). Pathologists are required to provide a reliable diagnosis of the tumor for clinicians who are responsible for the treatment of affected patients. Pathological diagnosis of diffuse malignant mesothelioma is not always easy; however, it has improved over the last few decades. Currently, comprehensive analysis, including gross appearance, histology, histochemistry, immunocyto-chemistry and electron microscopy is recommended as the best approach to an accurate diagnosis of diffuse malignant mesothelioma. Acta Pathol Jpn 42: 767–786, 1992.