冠心病病人外周血单核细胞镁浓度对心室重塑的影响

目的观察冠心病病人外周血单核细胞镁浓度、血清基质金属蛋白酶-9水平变化及其与心室重塑、心功能的关系.方法对78例冠心病病人,根据左室射血分数(LVEF)分为3组,1组 LVEF>0.50,2组LVEF>0.35,3组LVEF<0.35.测定病人外周血单核细胞内镁(Mg)及血清白细胞介素-6(IL-6)、基质金属蛋白酶-9(MMP-9)水平,超声测定左室收缩末期容量指数(LVESVI)、舒张末期容量指数(LVEDVI).结果随着LVEF降低,病人血单核细胞Mg降低,血清IL-6及MMP-9显著增高(P<0.05);LVEDVI、LVESVI与Mg均呈负相关(r=-0.49、-0.43,P<0.01),LVEDVI与IL-6、MMP-9呈正相关(r=0.41、0.47,P<0.01);Mg与IL-6及MMP-9均呈负相关(r=-0.47、-0.58,P<0.01).结论冠心病病人的心肌重塑及收缩功能障碍,可能与细胞内镁缺乏有关.

Effects of Magnesium of Peripheral Blood Monocyte on Ventricular Remodeling in Patients with Coronary Artery Disease

Objective To observe the concentration of ionized magnesium in peripheral monocyte and serum matrix metalloproteinase-9 level and relations to ventricular remodeling in patients (pts) with coronary artery disease (CHD).Methods 78 patients with CHD were randomly into three groups:Left ventricular ejection fraction (LVEF) > 0.50 in group 1;LVEF>0.35 in group 2;LVEF<0.35 in group 3.The left ventricular end-systolic-volume index (LVESVI) and left ventricular end diastolic volume index (LVEDVI) were measured by Echo-Doppler.The ionized magnesium of monocyte,serum interleukin -6 and matrix metalloproteinas-9 (MMP-9) level were collected.Results With the decrease of LVEF,the magnesium in monocyte decreased,serum interleukin-6 and MMP-9 levels increased significantly(P<0.05).LVEDVI and LVESVI were related to the intramonocyte magnesium negatively(r=-0.49,-0.43,P<0.01).LVEDVI was related to interleukin-6 and MMP-9 positively(r=0.41,0.47,P<0.01).The intramonocyte magnesium was related to interleukin-6 and M MP-9 negatively(r=-0.47,-0.58,P<0.01).Conclusion Cardiac remodeling and systolic dysfunction is related to the decrease of intramonocyte magnesium in patients with CHD.