鼻咽癌危险因子的危险度计算及其意义

目的 确定鼻咽癌主要危险因素及其综合危险度,用于估算个人患鼻咽癌的风险,为今后鼻咽癌的筛查和防治提供参考依据.方法 在电子数据库Pubmed和CBMDisc内中检索鼻咽癌相关文献,通过数据库检索和手工查阅纸质期刊的方式获取全文.通过综述性文献,结合鼻咽癌相关文献中的研究因素,确定鼻咽癌主要危险因素.筛选符合纳入标准的文...

The synthetical odds ratios for risk factors of nasopharyngeal carcinoma and it's application

Objective To find out main risk factors of nasopharyngeal carcinoma and estimate synthetical odds ratios （ORs） for them. The result can be used to assess individual risk for nasopharyngeal carcinoma and can provide reference for its screening and prevention. Methods To search published papers relevant to nasopharyngeal carcinoma in Pubmed and CBMDi- sc. By electronic database searching on computer and manual searching in library, full texts were got. By combining reviews and literatures related to risk factors for nasopharyngeal carcinoma, the main risk factors for nasopharyngeal carcinoma were con- firmed. To screen those papers which fit enroll-standard and do Meta analysis to estimate synthetical odds ratios （ORs） for risk factors of nasopharyngeal carcinoma. Results The main risk factors for nasopharyngeal carcinoma included family history, Ep- stein-Barr virus （VCA-IgA~〉I ： 10）, salted food eating （including salted fish, brawn, pickles, etc. ） and smoking. Totally 38 papers were brought into Meta analysis with 21 English ones and 17 Chinese ones respectively. These literatures were all 1 ： 1 case-control studies except 1 Cohort study and the study subjects were mainly Chinese. There were respectively 6, 20, 9 and 9 Papers used in Meta analysis for family history, Epstein-Barr virus, salted food eating and smoking. Except Epstein-Barr virus, the sex and age of the subjects match with one anther in relevant literatures. The heterogeneity test for the four risk factors were not significant（P〉0.05） and the ORs by fixed effect model for family history, Epstein-Barr virus, salted food eating and smoking was 7.20 （ 4.80, 10.81 ）, 131.34 （98.29,175.49）, 1.67 （ 1.47, 1.89） and 1.46 （ 1.30, 1.64） respectively. In addition, the safe number for family history, Epstein-Barr virus, salted food eating and smoking was 230, 18 986,218 and 131. Conclu- sion The ORs, combined with individual history, could be used to assess individual risks for nasopharyngeal carcinoma. Ac- cording to different individual risks, different screen measures would be adopted to prevent nasopharyngeal carcinoma, screening in high risk people would improve cost-effectiveness.