扶脾抑肝汤治疗糖尿病性腹泻临床研究

目的:观察扶脾抑肝汤治疗糖尿病性腹泻的临床疗效。方法:将100例糖尿病性腹泻患者随机分为对照组和观察组各50例,对照组给予整肠生胶囊,口服,每次3粒,每日3次,观察组给予扶脾抑肝汤,每日2次,分早晚口服。两组患者均连续治疗3个月,在治疗1个月和3个月时统计两组患者临床疗效。结果:治疗1个月后,对照组有效率为80.00%,观察组有效率为88.00%,两组有效率比较,差异无统计学意义(P0.05);治疗3个月后,对照组有效率为50.00%,观察组有效率为90.00%,两组有效率比较,差异有统计学意义(P0.05)。两组患者治疗后部分中医症状积分较治疗前降低,治疗前后比较,差异有统计学意义(P0.05),两组治疗后比较,差异有统计学意义(P0.05);两组患者治疗后空腹血糖(fasting plasma glucose,FPG)、餐后2小时血糖(2-hour postprandial blood glucose,2h PG)水平较治疗前降低,治疗前后比较,差异有统计学意义(P0.05);观察组治疗后FPG、2h PG水平与对照组治疗后比较,差异有统计学意义(P0.05)。两组患者治疗后肠道菌群计数与治疗前比较,差异有统计学意义(P0.05);观察组治疗后肠道菌群计数与对照组治疗后比较,差异有统计学意义(P0.05)。结论:扶脾抑肝汤可以提高糖尿病性腹泻患者的临床疗效,可以改善糖尿病性腹泻患者中医症状积分,降低FPG、2h PG水平,改善肠道菌群。

Clinical Study on Treatment of Diabetic Diarrhea by Invigorating Spleen and Regulating Liver Decoction

Objective:To observe the clinical effect of invigorating spleen and regulating liver decoction in the treatment of diabetic diarrhea.Methods:100 cases of patients with diabetic diarrhea were randomly divided into the control group and the treatment group with 50 cases in each group.The control group was given Zhengchangsheng capsule,3 capsules each time,3 times a day.The treatment group was given invigorating spleen and regulating liver decoction,2 times a day,taking decoction in the morning and evening.The two groups were treated continuously for 3 months.The clinical efficacy of the two groups was evaluated at 1 month and 3 months after treatment.Results:After 1 month treatment,the effective rate of the control group was 80.00％,and the treatment group was 88.00％.The difference between the two groups was not statistically significant (P ＞ 0.05);after 3 months treatment,the effective rate of the control group was 50.00％,and the treatment group was 90.00％.The difference between the two groups was statistically significant (P ＜ 0.05);after treatment,the symptom scores of two groups of patients were lower than before treatment,and the difference was statistically significant (P ＜ 0.05).The difference between the two groups after treatment was statistically significant (P ＜ 0.05);after treatment,fasting plasma glucose (FPG) and 2-hour postprandial blood glucose (2hPG)levels lower than before treatment(P ＜ 0.05),after treatment,the difference in the FPG,2hPG levels of the treatment group compared with the control group had statistical significance (P ＜ 0.05).Compared intestinal microflora count of the two groups of patients after treatment with before treatment showed that the difference was statistically significant (P ＜ 0.05).After treatment,there was statistical significance in the intestinal tract bacteria count of the two groups (P ＜ 0.05).Conclusion:The clinical curative effect of invigorating spleen and regulating liver decoction treatment of diabetic diarrhea is significant,positive correlation between curative effect and treatment time,which can improve clinical symptoms in patients with diabetic diarrhea,reduce FPG,2hPG level,improve the intestinal flora.