| 曲马朵药物依赖性和滥用潜力 |
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| 引用本文： | 刘志民 周伟华. 曲马朵药物依赖性和滥用潜力[J]. 中国药理学报, 1999, 20(1): 52-54 |
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| 作者姓名： | 刘志民 周伟华 |
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| 摘 要： | ![]()
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| 关 键 词： | 曲马朵 药物滥用 药物评价 麻醉剂 依赖性 |
Drug dependence and abuse potential of tramadol. |
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| Z M Liu,W H Zhou,Z Lian,Y Mu,Z H Ren,J Q Cao,Z J Cai. Drug dependence and abuse potential of tramadol.[J]. Acta Pharmacologica Sinica, 1999, 20(1): 52-54 |
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| Authors: | Z M Liu W H Zhou Z Lian Y Mu Z H Ren J Q Cao Z J Cai |
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| Affiliation: | National Institute on Drug Dependence, Beijing, China. zhiminliu@nidd.ac.cn |
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| Abstract: | ![]()
AIM: To assess the drug dependence and abuse liability of tramadol. METHODS: Subjects of opiate addicts with history of tramadol abuse were 219. Physical dependence of tramadol was assessed using opiate withdrawal scale (OWS), psychic dependence was assessed by association test of Addiction Research Center Inventory-Chinese Version (ARCI-CV); the degrees of craving experienced for tramadol was self-reported on visual analogue scale (VAS). RESULTS: The scores of OWS of tramadol were 0.05-1.07; 3 scores on scales in particular being used the identify euphoric effects--MBG, sedative effects--PCAG, and psychotomimetic effects--LSD of ARCI were 7.3, 6.1, and 3.4, respectively (F = 38.1, P < 0.01); 57.1% of tramadol abuse subjects had craving for tramadol (chi 2 = 75.86, P < 0.01). CONCLUSION: Tramadol produced high abuse potential among opiate addicts. |
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