| 康乐霉素C与环孢素对小鼠免疫抑制作用的比较 |
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| 引用本文： | 李建明 林志彬. 康乐霉素C与环孢素对小鼠免疫抑制作用的比较[J]. 中国药理学报, 1999, 20(1): 65-68 |
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| 作者姓名： | 李建明 林志彬 |
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| 摘 要： |
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| 关 键 词： | 康乐霉素C 环孢素 同种移植 免疫抑制 |
Kanglemycin C vs ciclosporin on immunosuppression in mice. |
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| J M Li,Z B Lin. Kanglemycin C vs ciclosporin on immunosuppression in mice.[J]. Acta Pharmacologica Sinica, 1999, 20(1): 65-68 |
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| Authors: | J M Li Z B Lin |
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| Affiliation: | Department of Pharmacology, Beijing Medical University, China. |
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| Abstract: | AIM: To study inhibitory effects of kanglemycin C (Kan) on the mouse immune system, and compare with the effects of ciclosporin (Cic). METHODS: Delayed hypersensitivity (DH) and cyclophosphamide-potentiated DH induced by dinitrofluorobenzene (DNFB); heart allograft and skin allograft; hemolysin; the phagocytosis of the peritoneal macrophage. RESULTS: Kan (12.5, 25, 50 mg.kg-1.d-1, ig, 8 d) markedly inhibited DH and cyclophosphamide-potentiated DH induced by DNFB (P < 0.01), prolonged survival times of heart and skin allografts (P < 0.01), and decreased the content of hemolysin (P < 0.01), but had no significant effect on the neutral-red phagocytosis of the peritoneal macrophage (P > 0.05). CONCLUSION: Kan had marked suppressive effects on cell-mediated and humoral-mediated immune responses, but no effect on phagocytosis of macrophage. |
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