| 阴道毛滴虫接触依赖性细胞毒性的分子作用及化学基础 |
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| 引用本文： | 杨树国,帖超男,王雅静. 阴道毛滴虫接触依赖性细胞毒性的分子作用及化学基础[J]. 中国寄生虫学与寄生虫病杂志, 2006, 24(5): 375-378 |
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| 作者姓名： | 杨树国 帖超男 王雅静 |
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| 作者单位： | 四川大学华西基础与法医学院寄生虫学教研室,成都,610041 |
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| 摘 要： | 阴道毛滴虫（以下简称滴虫）寄生于人体泌尿生殖道，在接触依赖性致病过程中，虫体对靶细胞的黏附起着关键性的作用，滴虫合成的酶分子可直接损伤上皮细胞，滴虫寄生部位的局部免疫反应可起到免疫保护作用，但炎症分子和免疫细胞又可加重病变损害，从整体水平来看，阴道毛滴虫的细胞毒性作用是多分子和多化学因素参与的共同结果。
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| 关 键 词： | 阴道毛滴虫 接触依赖性细胞毒性 致病机制 |
| 文章编号： | 1000-7423（2006）-05-0375-04 |
| 收稿时间： | 2005-12-30 |
| 修稿时间： | 2005-12-30 |
Molecular and Chemical Mechanism of Trichomonas vaginalis-inducedContact-dependent Cytotoxicity |
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| YANG Shu-guo,TIE Chao-nan,WANG Ya-jing. Molecular and Chemical Mechanism of Trichomonas vaginalis-inducedContact-dependent Cytotoxicity[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2006, 24(5): 375-378 |
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| Authors: | YANG Shu-guo TIE Chao-nan WANG Ya-jing |
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| Affiliation: | Department of Parasitology, School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China |
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| Abstract: | Trichomonas vaginalis parasitizes in human genitourinary tract.The protozoon adhering to target cell plays a critical role in its contact-dependent cytotoxicity.The enzymes synthesized by T.vaginalis can hurt vaginalis epithelial cells(VECs)directly.The focal immune reaction in the location parasitized by the parasite may provide an immunologic protection.Meanwhile,inflammatory factors and immune cells may aggravate the situation.In general,the T.vaginalis-induced contact-dependent cytotoxicity is a result of the involvement of some molecular and chemical factors. |
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| Keywords: | Trichomonas vaginalis Contact-dependent cytotoxicity Pathogenesis |
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