精浆NAG和血清FSH联合检测在梗阻性无精子症诊治中的应用

目的：探讨精浆中性α糖苷酶（NAG）和血清促卵泡生成素（FSH）联合检测在梗阻性无精子症诊断中的意义。方法分析24例男性无精子症患者（14例为梗阻性无精子症，10例为非梗阻性无精子症）精浆NAG和FSH 水平，与16例健康已生育男性（正常对照组）的检测结果进行相关性分析，同时结合睾丸体积和详细的病史资料判断无精子症病因及分型。结果无精子症患者（包括梗阻性和非梗阻性无精子症组）与正常对照组年龄差异无统计学意义（P＞0．05），非梗阻性无精子症组睾丸体积明显比梗阻性无精子症组和正常对照组小（P＜0．01）。无精子症患者NAG含量均明显低于正常对照组（P＜0．01），FSH 水平均明显高于正常对照组（P＜0．01）；梗阻性无精子症组NAG和血清FSH 水平明显低于非梗阻性无精子症组（P＜0．01）。结论精浆NAG和血清FSH 联合检测具有经济、快速、安全、无创等优点，对无精子症的诊断和临床指导治疗具有重要意义。

Significance of detecting seminal plasma neutral α-glucosidase and blood serum follicle-stimulating hormone in the diagnosis of patients with obstructive azoospermia

Objective To explore the significance of detecting seminal plasma neutral α-glucosidase （NAG） and blood serum fol- licle-stimulating hormone （FSH） in the diagnosis of patients with obstructive azoospermia. Methods In 24 cases with azoospermia and 16 cases of normal fertilize men（normal control group）, the detection of the concentration of NAG and FSH were combined with history and physical examination to diagnose the case of obstructive azoospermia. Results The level of age in the groups of ob- structed azoospermia,non-obstructed azoospermia and the normal control had no significant difference（P〈0.05）. But, the volume of testis in group of non-obstructed azoospermia were smaller than the groups of obstructed azoospermia and the normal control group（P〈0.01）. The concentration of NAG in azoospermia was significantly lower than the normal control group（P〈0.01）, and FSH was significantly higher than the normal control group（P〈0.01）. The concentration of NAG and FSH in the groups of ob- structed azoospermia were lower than the group of non-obstructed azoospermia（P〈0.01）. Conclusion Detection of seminal plasma NAG and blood serum FSH are significant for economic, speedy, safe, non-invasive and guide treatment in etiological diagnosis of obstructive azoospermia.