| Abstract: | The average percentage of spontaneous plasmid-negative variants in an initial resistant population of staphylococci developingin vitro was 0.9±0.2 in broth and 1.2±0.3 in exudate; developingin vivo, in a subcutaneous suppurative inflammatory focus it was 6.3±2.0 and in the kidneys 9.5±2.6. The average percentage of spontaneous plasmid-negative variants in purulent exudatein vivo was significantly higher than in purulent exudatein vitro. The frequency of appearance of these variantsin vivo depends on the properties of the host.Gamaleya Institute of Epidemiology and Microbiology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR G. V. Vygodchikov.) Translated from Byulleten' Éxperimental'noi Biologii i Meditsiny, Vol. 86, No. 10, pp. 452–454, October, 1978. |
