延边地区慢性丙型肝炎患者血清中自身抗体的检测及其临床意义

目的:分析延边地区慢性丙型肝炎患者血清中自身抗体阳性率及其临床意义.方法:选择100名慢性丙型肝病患者(慢性79例,肝硬化21例),检测自身抗体(ALC,ANA,ASA,AMA,RF)阳性率,并比较自身抗体( )及自身抗体(-)群年龄、性别、肝功能状态.结果:慢性丙型肝炎患者血清中自身抗体至少一种阳性的62例.ACL阳性40例最多,其次为ANA阳性29例,RF阳性19例,ASA阳性8例,AMA阳性3例.另外,自身抗体阳性组和阴性组有关因素比较发现,自身抗体阳性组比阴性组年龄较大(58.7岁vs49.7岁)、女性多见(79.2%vs46.2%)、肝功能及肝病状态差.结论:慢性丙型肝炎患者血清中常出现自身抗体,自身抗体出现可影响肝功能状态,加重病情,在临床诊疗中应慎重.

Detection and clinical significance of autoantibodies in serum of patients with chronic Hepatitis C in Yanbian area

AIM: To analyze the positive rate of autoantibodies in patients with chronic chronic Hepatitis C and their clini-cal signif icances.METHODS: The positive rate of autoantibodies in-cluding anti-cardiolipin (ALC), antinuclear (ANA), an-ti-smooth muscle (ASA), antimitochondrial (AMA) an-tibodies, and rheumatiod factor (RF) were detected in 100 patients with chronic Hepatitis C (79 chronic hepatitis C, 21 liver cirrhosis). And the factors such as age, gender, and liver function, between patients with autoantibodies positive and negative were com-pared.RESULTS: The overall positive rate of the autoanti-bodies was 62.0%. The positive rate of ACL, ANA, RF, ASA, and AMA was 40.0%, 29.0%, 19.0%, 8.0%, and 3.0%, respectively. As compared with the autoantibody-negative patients, the autoantibody-positive patients were order (58.7 vs 49.7), and with worse liver function and disease status. The positive expression of autoan-tibody was found higher in females than those in males (79.2% vs 46.2%).CONCLUSION: The autoantibodies are commonly found in patients with chronic hepatitis C. Its presence may infect the status of the liver function and aggra-vate the state of the disease.