连续性肺部混合磨玻璃结节影19例临床分析

目的：研究肺部混合磨玻璃结节影（mixed ground-glass opacity，mGGO）的疾病构成、诊断技术及疾病与影像学特点关系。方法前瞻性研究经病理证实的19例连续性肺部mGGO病例的基本临床资料、影像学特征（包括病灶大小、边缘特征、GGO百分比、内部特征、邻近特征、结节外表现）。根据确诊结果分为良性病变组和恶性病变组，并比较上述观察指标。结果19例肺部mGGO结节中良性病变4例（良性病变组），恶性15例（恶性病变组）。恶性病变组中CT表现分叶征（86.7％）、边界清楚（86.7％）和血管集束征（80.0％）明显高于良性病变组。恶性病变组GGO百分比≤50％为14例，良性病变组仅1例（P＝0.016）。基本临床资料、病灶大小、部位、内部特征、结节外表现及结节至壁层胸膜距离在良恶性病变组中均无差异（P均＞0.05）。11例CT引导经皮穿刺肺活检均获确诊。结论肺部mGGO结节的CT表现对病变性质鉴别诊断有一定意义。经皮穿刺肺活检术对肺部mGGO结节确诊率高。

Clinical analysis of 19 consecutive cases of pulmonary mixed ground-glass opacity nodules

Objective To investigate the proportion and diagnostic techniques of pulmonary mixed ground -glass opacity（mGGO）, and the relationship between the disease and computed tomography （CT） characteristics. Methods Single mGGO were found in 22 consecutive patients which underwent multi-detector CT.Nineteen （ 86.4%） consecutive cases of mGGO nodules that were histologically confirmed were included in this prospective tri -al.All cases of pulmonary mGGO nodules were divided into two groups：malignant nodules group and benign nodules group.The clinical and radiological characteristics （ including the lesions′size, edge characteristics , internal charac-teristics, etc） of all patients were recorded .These parameters were statistically compared between the two groups .Re-sults There were 4 benign and 15 malignant mGGOs .No statistical differences were found between benign and ma-lignant mGGOs in terms of demographic data , lesions′size, internal characteristics and external manifestations .The frequency of lobulation （ 86.7%） , well-defined interface （ 86.7%） and vascular convergence （ 80.0%） was signifi-cantly higher in malignant mGGOs than that in benign mGGOs .The percentage of GGO component ≤50%was high-er in malignant mGGOs.The diagnostic of 11 cases were confirmed through percutaneous core needle lung biopsy un-der multi-CT fluoroscopic guidance .Conclusion The CT characteristics of pulmonary mGGO nodules have certain significance in the differential diagnosis of lesions properties of pulmonary mGGO nodules .CT fluoroscopy-guided needle aspiration biopsy is a useful diagnostic technique for mGGO nodules .